mAtNOS1 induces apoptosis of human mammary adenocarcinoma cells
| Autor: | Zhonghai Chen, Pedram Ghafourifar, Mordhwaj S. Parihar, Arti Parihar |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
chemistry.chemical_element
Apoptosis Breast Neoplasms Adenocarcinoma Mitochondrion Calcium Mammary adenocarcinoma Nitric Oxide Transfection Mitochondrial apoptosis-induced channel General Biochemistry Genetics and Molecular Biology Nitric oxide chemistry.chemical_compound Cell Line Tumor Humans General Pharmacology Toxicology and Pharmaceutics biology Arabidopsis Proteins Immunochemistry Cytochrome c Cytochromes c General Medicine Mitochondria Cell biology chemistry biology.protein Tyrosine Female Nitric Oxide Synthase Function (biology) |
| Zdroj: | Life Sciences. 82:1077-1082 |
| ISSN: | 0024-3205 |
| Popis: | mAtNOS1 is a novel gene recently reported in mammalian genome with functions that are not fully understood. The present study shows that in human mammary adenocarcinoma MCF-7 cells, mAtNOS1 expression increases mitochondrial nitric oxide and calcium. Our study further shows that overexpression of mAtNOS1 induces apoptosis in MCF-7 cells by increasing mitochondrial protein tyrosine nitration and cytochrome c release. The present study suggests a novel function for mAtNOS1 in regulating mitochondrial nitric oxide and calcium and inducing apoptosis of MCF-7 cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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