Gli1 + Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury
| Autor: | Flavia Gomes Machado, Benjamin D. Humphreys, Monica Chang-Panesso, Janewit Wongboonsin, Rafael Kramann |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Pathology medicine.medical_specialty Kidney biology Chemistry Vimentin General Medicine Endothelial stem cell 03 medical and health sciences 030104 developmental biology medicine.anatomical_structure Nephrology GLI1 biology.protein medicine Capillary Rarefaction Proximal tubule Pericyte Genetic ablation |
| Zdroj: | Journal of the American Society of Nephrology |
| ISSN: | 1046-6673 |
| DOI: | 10.1681/ASN.2016030297 |
| Popis: | Peritubular capillary rarefaction is hypothesized to contribute to the increased risk of future CKD after AKI. Here, we directly tested the role of Gli1+ kidney pericytes in the maintenance of peritubular capillary health, and the consequences of pericyte loss during injury. Using bigenic Gli1-CreERt2; R26tdTomato reporter mice, we observed increased distance between Gli1+ pericytes and endothelial cells after AKI (mean±SEM: 3.3±0.1 µm before injury versus 12.5±0.2 µm after injury; P |
| Databáze: | OpenAIRE |
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