Diagnostic and prognostic value of serum procalcitonin concentrations in primary lung cancers

Autor: B. Cauliez, S. Bota, Luc Thiberville, Maxime Patout, V. Brunel, Mathieu Salaün
Přispěvatelé: Equipe Quantification en Imagerie Fonctionnelle (QuantIF-LITIS), Laboratoire d'Informatique, de Traitement de l'Information et des Systèmes (LITIS), Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Institut National des Sciences Appliquées (INSA)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Université Le Havre Normandie (ULH), Normandie Université (NU)-Institut national des sciences appliquées Rouen Normandie (INSA Rouen Normandie), Normandie Université (NU), Centre de Recherche en Économie et Statistique (CREST), Ecole Nationale de la Statistique et de l'Analyse de l'Information [Bruz] (ENSAI)-École polytechnique (X)-École Nationale de la Statistique et de l'Administration Économique (ENSAE Paris)-Centre National de la Recherche Scientifique (CNRS), Service de pneumologie, oncologie thoracique et soins intensifs respiratoires [Rouen], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Hôpital Charles Nicolle [Rouen]-CHU Rouen
Rok vydání: 2014
Předmět:
Male
Pathology
Lung Neoplasms
[SDV]Life Sciences [q-bio]
Clinical Biochemistry
Kaplan-Meier Estimate
Gastroenterology
Procalcitonin
0302 clinical medicine
Liver metastasis
Prognostic factor
0303 health sciences
education.field_of_study
Liver Neoplasms
General Medicine
Middle Aged
Prognosis
3. Good health
Predictive factor
Neuroendocrine Tumors
medicine.anatomical_structure
030220 oncology & carcinogenesis
Female
hormones
hormone substitutes
and hormone antagonists
Calcitonin
congenital
hereditary
and neonatal diseases and abnormalities
medicine.medical_specialty
Calcitonin Gene-Related Peptide
Enolase
Population
[SDV.CAN]Life Sciences [q-bio]/Cancer
Adenocarcinoma
Sensitivity and Specificity
Small-cell lung cancer
Diagnosis
Differential
03 medical and health sciences
Internal medicine
parasitic diseases
Biomarkers
Tumor
medicine
Humans
In patient
Protein Precursors
Lung cancer
education
Aged
Retrospective Studies
030304 developmental biology
Lung
business.industry
bacterial infections and mycoses
medicine.disease
Serum samples
Small Cell Lung Carcinoma
Multivariate Analysis
business
Non-small-cell lung cancer
Zdroj: Clinical Biochemistry
Clinical Biochemistry, Elsevier, 2014, 47 (18), pp.263-7
ISSN: 0009-9120
1873-2933
DOI: 10.1016/j.clinbiochem.2014.09.002
Popis: International audience; Procalcitonin (PCT) is widely used for the diagnosis of bacterial infections. The aim of this study was to evaluate PCT as a tumor and as a prognostic marker in patients with primary lung cancer. We retrospectively performed a PCT dosage in the frozen serum samples of 147 patients with pulmonary neoplasia for whom a test of neuron-specific enolase (NSE) had been conducted at the time of diagnosis. We show that a PCT serum level above 0.15 ng/mL was independently linked to the presence of a neuroendocrine component in the tumor (HR=5.809 95% CI [1.695-19.908] p: 0005). Thus, median PCT serum levels were significantly more elevated in small-cell lung cancers than in pulmonary adenocarcinomas: 0.33 ng/mL versus 0.07 ng/mL (p
Databáze: OpenAIRE
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