Comprehensive Analysis of the Expression and Prognostic Value of SPINT1/2 in Breast Carcinoma
| Autor: | Jinwei Lei, Jing Luo, Yudi Jin, Guobing Yin, Shengchun Liu, Jiao Tian, Qiulin Wu, Yingzi Zhang, Tiantian Ai |
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| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Endocrinology Diabetes and Metabolism Cell Proteinase Inhibitory Proteins Secretory Breast Neoplasms Biology medicine.disease_cause Diseases of the endocrine glands. Clinical endocrinology 03 medical and health sciences 0302 clinical medicine Breast cancer Endocrinology breast cancer medicine Biomarkers Tumor Humans KEGG Gene Original Research functions Membrane Glycoproteins Cancer SPINT2 SPINT1 medicine.disease RC648-665 Prognosis Gene Expression Regulation Neoplastic Survival Rate 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Case-Control Studies Cancer research Hepatocyte growth factor Female Breast carcinoma Carcinogenesis medicine.drug Follow-Up Studies |
| Zdroj: | Frontiers in Endocrinology Frontiers in Endocrinology, Vol 12 (2021) |
| ISSN: | 1664-2392 |
| Popis: | BackgroundHepatocyte growth factor (HGF) signaling plays a plethora of roles in tumorigenesis and progression in many cancer types. As HGF activator inhibitors, serine protease inhibitor, Kunitz types 1 and 2 (SPINT1 and SPINT2) have been reported to be differentially expressed in breast cancer, but their prognostic significance and functioning mechanism remain unclear.MethodsIn our study, multiple databases and bioinformatics tools were used to investigate SPINT1/2 expression profiles, prognostic significance, genetic alteration, methylation, and regulatory network in breast carcinoma.ResultsSPINT1/2 expression was upregulated in breast cancer, and was relatively higher in human epidermal growth factor receptor 2 (HER2) and node positive patients. Elevated SPINT1/2 expression was significantly correlated with a poorer prognosis. Genetic alterations and SPINT1/2 hypomethylation were observed. In breast carcinoma, SPINT1/2 were reciprocally correlated and shared common co-expressed genes. Gene ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis showed that their common co-expressed genes were primarily involved in regulating cell attachment and migration.ConclusionsOur study identified the expression profiles, prognostic significance and potential roles of SPINT1/2 in breast carcinoma. These study results showed that the SPINT1/2 were potential prognostic biomarker for patients with breast cancer. |
| Databáze: | OpenAIRE |
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