Laser-triggered intraocular implant to induce photodynamic therapy for posterior capsule opacification prevention
| Autor: | Ming Lei, Zhaoguo Zhang, Yuanfeng He, Xuefei Zhang, Mina Yan, Chunshun Zhao, Wenyong Huang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Indocyanine Green
medicine.medical_specialty genetic structures Cell Survival medicine.medical_treatment Pharmaceutical Science Photodynamic therapy 02 engineering and technology Prosthesis Design 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Lens Implantation Intraocular Polylactic Acid-Polyglycolic Acid Copolymer In vivo Ophthalmology Animals Humans Medicine Lactic Acid Viability assay Posterior capsule opacification Cells Cultured business.industry Lasers Intraocular implant Capsule Opacification 021001 nanoscience & nanotechnology eye diseases Rats Surgery body regions PLGA Photochemotherapy chemistry Pharmacodynamics 030221 ophthalmology & optometry Rabbits sense organs 0210 nano-technology business Indocyanine green Polyglycolic Acid |
| Zdroj: | International Journal of Pharmaceutics. 498:1-11 |
| ISSN: | 0378-5173 |
| Popis: | Posterior capsule opacification (PCO) is one of the main reasons for loss of vision again after cataract surgery. In this study, intraocular lenses were modified with indocyanine green (ICG) and sealed up with PLGA to form long-term intraocular implants (ICG-IOL). When triggered by laser, ICG-IOL would induce photodynamic therapy (PDT). In-vitro cell viability assay and scratch wound healing assay demonstrated that ICG-IOL could effectively inhibit HLEpiC proliferation and migration without causing damage to the cells far away from it. Laser attenuation test indicated that ICG-IOL could be applied in vivo. In-vivo pharmacodynamics and safety study showed that ICG-IOL could significantly prevent the occurrence of PCO and was safe for intraocular normal tissue. All these results suggested that ICG-IOL would be a very promising candidate for PCO prevention. |
| Databáze: | OpenAIRE |
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