Pathological Mechanisms and Potential Therapeutic Targets of Pulmonary Arterial Hypertension: A Review
| Autor: | Zhuang Tian, Shuyang Zhang, Peipei Chen, Ying Xiao, Yang Zhang, Rui-Lin Zhou |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Inflammation Review Article Disease hemodynamics Bioinformatics Pathology and Forensic Medicine Nitric oxide Pathogenesis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Germline mutation pulmonary arterial hypertension Medicine Pathological Survival rate business.industry therapy advances Mortality rate Cell Biology 030104 developmental biology chemistry right ventricular dysfunction Neurology (clinical) Geriatrics and Gerontology medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Aging and Disease |
| ISSN: | 2152-5250 |
| DOI: | 10.14336/ad.2020.0111 |
| Popis: | Pulmonary arterial hypertension (PAH) is a progressive cardiovascular disease characterized by pulmonary vasculature reconstruction and right ventricular dysfunction. The mortality rate of PAH remains high, although multiple therapeutic strategies have been implemented in clinical practice. These drugs mainly target the endothelin-1, prostacyclin and nitric oxide pathways. Management for PAH treatment includes improving symptoms, enhancing quality of life, and extending survival rate. Existing drugs developed to treat the disease have resulted in enormous economic and healthcare liabilities. The estimated cost for advanced PAH has exceeded $200,000 per year. The pathogenesis of PAH is associated with numerous molecular processes. It mainly includes germline mutation, inflammation, dysfunction of pulmonary arterial endothelial cells, epigenetic modifications, DNA damage, metabolic dysfunction, sex hormone imbalance, and oxidative stress, among others. Findings based on the pathobiology of PAH may have promising therapeutic outcomes. Hence, faced with the challenges of increasing healthcare demands, in this review, we attempted to explore the pathological mechanisms and alternative therapeutic targets, including other auxiliary devices or interventional therapies, in PAH. The article will discuss the potential therapies of PAH in detail, which may require further investigation before implementation. |
| Databáze: | OpenAIRE |
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