The value of subtraction MRI in detection of amyloid-related imaging abnormalities with oedema or effusion in Alzheimer’s patients:An interobserver study

Autor: Derk D. Purcell, Frederik Barkhof, Roland M. Martens, Silvia Ingala, Arianne Bechten, Robert H. Brashear, Esther Sanchez, Mike P. Wattjes, Michael Arrighi, Ronald A. van Schijndel, Vania B. Machado, Marcus C. de Jong
Přispěvatelé: Radiology and nuclear medicine, Amsterdam Neuroscience - Neurodegeneration
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
medicine.medical_specialty
animal structures
Intraclass correlation
Brain Edema
Antibodies
Monoclonal
Humanized
030218 nuclear medicine & medical imaging
03 medical and health sciences
0302 clinical medicine
Double-Blind Method
Alzheimer Disease
Rating scale
medicine
Humans
Amyloid beta (Aβ)
Radiology
Nuclear Medicine and imaging
Bapineuzumab
Aged
Neuroradiology
ARIA (amyloid-related imaging abnormalities)
Dose-Response Relationship
Drug
business.industry
Ultrasound
MRI (magnetic resonance imaging)
Subtraction
Brain
Reproducibility of Results
Amyloidosis
General Medicine
Magnetic Resonance Imaging
Hyperintensity
ROC Curve
Effusion
Alzheimer's disease (AD)
Injections
Intravenous
Female
Immunotherapy
Radiology
Neuro
Nuclear medicine
business
030217 neurology & neurosurgery
Follow-Up Studies
medicine.drug
Zdroj: Martens, R M, Bechten, A, Ingala, S, van Schijndel, R A, Machado, V B, de Jong, M C, Sanchez, E, Purcell, D, Arrighi, M H, Brashear, R H, Wattjes, M P & Barkhof, F 2018, ' The value of subtraction MRI in detection of amyloid-related imaging abnormalities with oedema or effusion in Alzheimer’s patients : An interobserver study ', European Radiology, vol. 28, no. 3, pp. 1-12 . https://doi.org/10.1007/s00330-017-5022-6
European Radiology, 28(3), 1-12. Springer Verlag
European Radiology
ISSN: 0938-7994
Popis: Background: Immunotherapeutic treatments targeting amyloid-β plaques in Alzheimer’s disease (AD) are associated with the presence of amyloid-related imaging abnormalities with oedema or effusion (ARIA-E), whose detection and classification is crucial to evaluate subjects enrolled in clinical trials. Purpose: To investigate the applicability of subtraction MRI in the ARIA-E detection using an established ARIA-E-rating scale. Methods: We included 75 AD patients receiving bapineuzumab treatment, including 29 ARIA-E cases. Five neuroradiologists rated their brain MRI-scans with and without subtraction images. The accuracy of evaluating the presence of ARIA-E, intraclass correlation coefficient (ICC) and specific agreement was calculated. Results: Subtraction resulted in higher sensitivity (0.966) and lower specificity (0.970) than native images (0.959, 0.991, respectively). Individual rater detection was excellent. ICC scores ranged from excellent to good, except for gyral swelling (moderate). Excellent negative and good positive specific agreement among all ARIA-E imaging features was reported in both groups. Combining sulcal hyperintensity and gyral swelling significantly increased positive agreement for subtraction images. Conclusion: Subtraction MRI has potential as a visual aid increasing the sensitivity of ARIA-E assessment. However, in order to improve its usefulness isotropic acquisition and enhanced training are required. The ARIA-E rating scale may benefit from combining sulcal hyperintensity and swelling. Key Points: • Subtraction technique can improve detection amyloid-related imaging-abnormalities with edema/effusion in Alzheimer’s patients.• The value of ARIA-E detection, classification and monitoring using subtraction was assessed.• Validation of an established ARIA-E rating scale, recommendations for improvement are reported.• Complementary statistical methods were employed to measure accuracy, inter-rater-reliability and specific agreement.
Databáze: OpenAIRE
Externí odkaz: