Combined Administration of Streptozotocin and Sucrose Accelerates the Appearance of Type 2 Diabetes Symptoms in Rats
| Autor: | Berenice Illades-Aguiar, Mónica Espinoza-Rojo, Mónica Ramírez, Penélope Aguilera, Martha Isela Barragán-Bonilla, Juan Miguel Mendoza-Bello, Isela Parra-Rojas |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Blood Glucose
Male 0301 basic medicine Sucrose medicine.medical_specialty Article Subject Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism Type 2 diabetes lcsh:Diseases of the endocrine glands. Clinical endocrinology Streptozocin Diabetes Mellitus Experimental 03 medical and health sciences 0302 clinical medicine Endocrinology Insulin resistance Polyuria Diabetes mellitus Internal medicine Animals Insulin Medicine Rats Wistar Glucose tolerance test lcsh:RC648-665 medicine.diagnostic_test business.industry Body Weight Glucose Tolerance Test Streptozotocin medicine.disease Rats Disease Models Animal 030104 developmental biology Polyphagia Diabetes Mellitus Type 2 Hyperglycemia Female Insulin Resistance medicine.symptom business Polydipsia Research Article medicine.drug |
| Zdroj: | Journal of Diabetes Research, Vol 2019 (2019) Journal of Diabetes Research |
| ISSN: | 2314-6753 2314-6745 |
| Popis: | Type 2 diabetes is a disease with a high global prevalence, characterized by chronic hyperglycemia, insulin resistance, polyphagia, polydipsia, polyuria, and changes in body weight. Animal models have been very useful for the study of this disease and to search for new therapeutic targets that delay, attenuate, or avoid diabetic complications. The purpose of this work was to establish a model of type 2 diabetes and exhibit the majority of the characteristics of the disease. Two-day-old male and female Wistar rats were treated once with streptozotocin (70 or 90 mg/kg body weight). After weaning, they were given a sucrose-sweetened beverage (SSB; sucrose at 10 or 30%) during 7 or 11 weeks; their body weight and food intake were measured daily. With the rats at 14 weeks of age, we determined the following: (a) fasting blood glucose, (b) oral glucose tolerance, and (c) insulin tolerance. We found that the supplementation of sucrose at 10% for 7 weeks in male rats which had previously been given streptozotocin (70 mg/kg) at neonatal stage leads to the appearance of the signs and symptoms of the characteristic of type 2 diabetes in adulthood. |
| Databáze: | OpenAIRE |
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