The influence of a wide range of dietary protein concentration on the acute oral toxicity of malathion
| Autor: | T. K. Tanikella, C. J. Krijnen, Eldon M. Boyd |
|---|---|
| Rok vydání: | 1970 |
| Předmět: |
Bridged-Ring Compounds
Male Insecticides Indoles Diazinon Health Toxicology and Mutagenesis Administration Oral Benzothiepins Naphthalenes Toxicology Pesticide toxicity chemistry.chemical_compound Animal science Casein Carbaryl Animals Urea Weaning Anilides Phosphoric Acids Captan Thiomalates Terpenes Caseins General Medicine people.cause_of_death Rats Pyrimidines chemistry Toxicity Malathion Carbamates Dietary Proteins people Hexachlorocyclohexane |
| Zdroj: | F�hner-Wielands Sammlung von Vergiftungsf�llen Archiv f�r Toxikologie. 26:125-132 |
| ISSN: | 1432-0738 0340-5761 |
| DOI: | 10.1007/bf00577798 |
| Popis: | Male albino rats were fed for 28 days from weaning on a diet containing 0% casein (group I), 3.5% casein (group II), 9% casein (group III), 26% casein (group IV), or 81% casein (group V). At the end of the dieting period, the LD50±S. E. of malathion, in mg/kg body weight, was found to be 539±42 in group I, 599±138 in group II, 759±91 in group III, 1401±99 in group IV, and 649±51 in group V. The interval to death and the clinicopathologic signs of toxicity to malathion were essentially the same in all five dietary groups. The results were compared with corresponding available data on other pesticides including captan. carbaryl. diazinon, dicophane, endosulfan, lindane and on the herbicides chlorpropham and monuron. The toxicity of these agents was not markedly increased until dietary protein was reduced to less than one third of normal or optima intake. At levels of one seventh, or less, of normal dietary protein, toxicity of al agents was increased but to some (e.g. captan) much more than to others (e.g. malathion). The high casein diet of group V was toxic to albino rats when feeding was started at weaning but not if feeding was started 2–3 weeks after waning. |
| Databáze: | OpenAIRE |
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