Serum Angiopoietin-2 and CRP Levels During COPD Exacerbations
| Autor: | Davina Camargo Madeira Simoes, Konstantinos Kostikas, Georgios Hillas, Nikolaos Tentolouris, Erasmia Georgakopoulou, Dimitrios Veldekis, Petros Bakakos, Evaggelos Vogiatzakis, Sofia Nikolakopoulou, Despina Perrea, Stylianos Loukides |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Spirometry medicine.medical_specialty Exacerbation Systemic inflammation Severity of Illness Index Angiopoietin-2 Cohort Studies Pulmonary Disease Chronic Obstructive Internal medicine Severity of illness Humans Medicine Prospective Studies Prospective cohort study Aged COPD medicine.diagnostic_test biology business.industry C-reactive protein Middle Aged medicine.disease C-Reactive Protein Immunology Disease Progression biology.protein Female medicine.symptom business Biomarkers Cohort study |
| Zdroj: | COPD: Journal of Chronic Obstructive Pulmonary Disease. 11:46-51 |
| ISSN: | 1541-2563 1541-2555 |
| DOI: | 10.3109/15412555.2013.829436 |
| Popis: | Angiopoietin-2 (Ang-2) is an important mediator of angiogenesis and has been implicated in many inflammatory diseases. COPD is characterized by systemic inflammation, which is enhanced during exacerbations and may be assessed by measuring serum C-reactive protein (CRP). The aim of the study was to evaluate serum CRP and Ang-2 levels on the first (D1) and seventh day (D7) of hospitalization due to a COPD exacerbation and to examine possible associations of CRP and Ang-2 levels and kinetics with the length of hospital stay and outcome.We conducted a prospective study and evaluated 90 patients admitted to the hospital with a diagnosis of an acute exacerbation of COPD. A venous blood sample was obtained from all patients on D1 and D7 of hospitalization, for the measurement of Ang-2 and CRP.Serum Ang-2 levels were significantly higher on D1 compared to D7 during the course of COPD exacerbation (p0.001). Serum CRP levels were also significantly higher on D1 compared to D7 (p0.001). Serum Ang-2 presented a significant positive correlation with CRP levels both on D1 and D7 (r = 0.315 and r = 0.228, respectively). Patients with unfavorable outcome had significantly higher Ang-2 levels both on D1 (p = 0.04) and D7 (p = 0.01).Serum Ang-2 levels are elevated at the onset of COPD exacerbations and are positively associated with CRP levels. Ang-2 levels decrease during the course of COPD exacerbations in patients with favorable outcome. Serum Ang-2 may serve as a biomarker that could predict the outcome of a COPD exacerbation. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|