Local concentrations of gentamicin obtained by microdialysis after a controlled application of a GentaColl sponge in a porcine model
| Autor: | Lasse B. Krag, Maiken Stilling, Mats Bue, Carsten S. Højskov, Kjeld Søballe, Pelle Hanberg, Klaus Kjær Petersen, Maja B. Thomassen |
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| Rok vydání: | 2020 |
| Předmět: |
Surgical Sponges
PHARMACOKINETICS Microdialysis microdialysis Swine Epiphyseal plate 0206 medical engineering 02 engineering and technology gentamicin PROPHYLAXIS Bone and Bones law.invention Intramedullary rod 03 medical and health sciences 0302 clinical medicine tissue penetration FRACTURES law medicine SURGICAL SITE INFECTION Animals Surgical Wound Infection CEFUROXIME Orthopedic Procedures Orthopedics and Sports Medicine 030203 arthritis & rheumatology Chemistry Venous blood 020601 biomedical engineering infection Anti-Bacterial Agents IMPLANT-ASSOCIATED OSTEOMYELITIS medicine.anatomical_structure TISSUE Female Cortical bone Gentamicin PENETRATION Gentamicins BONE Cancellous bone Biomedical engineering Subcutaneous tissue medicine.drug |
| Zdroj: | Thomassen, M B, Hanberg, P, Stilling, M, Petersen, K K, Søballe, K, Krag, L B, Højskov, C S & Bue, M 2020, ' Local concentrations of gentamicin obtained by microdialysis after a controlled application of a GentaColl sponge in a porcine model ', Journal of Orthopaedic Research, vol. 38, no. 8, pp. 1793-1799 . https://doi.org/10.1002/jor.24588 |
| ISSN: | 1554-527X 0736-0266 |
| DOI: | 10.1002/jor.24588 |
| Popis: | Local treatment with gentamicin may be an important tool in the prevention and treatment of surgical site infections in high-risk procedures and patients. The aim of this study was to evaluate the pharmacokinetic profile of gentamicin in bone and surrounding tissue, released from a controlled application of a GentaColl sponge in a porcine model. In eight female pigs, a GentaColl sponge of 10 × 10 cm (1.3 mg gentamicin/cm 2) was placed in a cancellous bone cavity in the proximal tibia. Microdialysis was used for sampling of gentamicin concentrations over 48 hours from the cavity with the implanted GentaColl sponge, cancellous bone parallel to the cavity over and under the epiphyseal plate, cortical bone, the intramedullary canal, subcutaneous tissue, and the joint cavity of the knee. Venous blood samples were obtained as reference. The main finding was a mean peak drug concentration (95% CI) of gentamicin in the cancellous bone cavity containing the implanted GentaColl sponge of 11 315 (9049-13 581) μg/mL, persisting above 1000 μg/mL until approximately 40 hours after application. Moreover, the concentrations were low ( |
| Databáze: | OpenAIRE |
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