Hox gene expression in teleost fins and the origin of vertebrate digits
| Autor: | Denis Duboule, F. van der Hoeven, Paolo Sordino |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
animal structures
Mutant Morphogenesis Danio Gene Expression Tetrapod Mesoderm Mice Forelimb Animals Hedgehog Proteins Hox gene Zebrafish Homeodomain Proteins Genetics Multidisciplinary biology Genes Homeobox Proteins Extremities biology.organism_classification Biological Evolution Hindlimb Cell biology body regions Vertebrates embryonic structures Trans-Activators Homeotic gene Limb morphogenesis |
| Zdroj: | Nature. 375:678-681 |
| ISSN: | 1476-4687 0028-0836 |
| DOI: | 10.1038/375678a0 |
| Popis: | Hox genes are essential for growth and patterning of the tetrapod limb skeleton. Mice mutant for the Hoxd-13 gene have an important delay in morphogenesis owing to reduced proliferation. Based on the appearance of atavisms in such mice, we suggested that modifications of Hox gene regulation may have been a source of morphological variation during the evolution of tetrapod limbs. Pectoral and pelvic fins are homologous to fore- and hindlimbs, respectively. To compare the relative importance of Hox genes during fin versus limb morphogenesis, we cloned zebrafish (Danio rerio) HoxD and HoxA complex genes and analysed their expression during fin development. The results suggest a scheme for the fin-limb transition in which the distal autopods (digits) are neomorphic structures produced by unequal proliferation of the posterior part of an ancestral appendix. |
| Databáze: | OpenAIRE |
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