Activation of catalase by apelin prevents oxidative stress-linked cardiac hypertrophy

Autor: Philippe Valet, Angelo Parini, Atul Pathak, Oksana Kunduzova, Céline Guilbeau-Frugier, Denis Calise, Camille Foussal, Olivier Lairez
Přispěvatelé: Simon, Marie Francoise, Institut de médecine moléculaire de Rangueil (I2MR), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées- Institut Fédératif de Recherche Bio-médicale Institution (IFR150)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Microchirurgie Expérimentale, Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)- Institut Fédératif de Recherche Bio-médicale Institution (IFR150), Service d'anatomie pathologique et histologie-cytologie [Rangueil], Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)
Rok vydání: 2010
Předmět:
Pressure overload
MESH: Myocytes
Cardiac
Adipose tissue
medicine.disease_cause
Left ventricular hypertrophy
Biochemistry
Muscle hypertrophy
Mice
Structural Biology
Myocytes
Cardiac
MESH: Animals
chemistry.chemical_classification
MESH: Oxidative Stress
MESH: Hypertrophy
biology
Chemistry
MESH: Reactive Oxygen Species
Catalase
Apelin
MESH: Hydrogen Peroxide
Hypertrophy
Left Ventricular
MESH: Hypertrophy
Left Ventricular
Serotonin
medicine.medical_specialty
MESH: Myocardium
MESH: Rats
Biophysics
Cardiomegaly
Cardiomyocyte
MESH: Catalase
Internal medicine
[SDV.BBM] Life Sciences [q-bio]/Biochemistry
Molecular Biology
Genetics
medicine
Animals
[SDV.BBM]Life Sciences [q-bio]/Biochemistry
Molecular Biology
MESH: Mice
Molecular Biology
Reactive oxygen species
Myocardium
Hydrogen Peroxide
Hypertrophy
Cell Biology
medicine.disease
Rats
Oxidative Stress
Endocrinology
biology.protein
MESH: Serotonin
MESH: Cardiomegaly
Reactive Oxygen Species
Oxidative stress
Zdroj: FEBS Letters
FEBS Letters, 2010, 584 (11), pp.2363-70. ⟨10.1016/j.febslet.2010.04.025⟩
ISSN: 0014-5793
1873-3468
DOI: 10.1016/j.febslet.2010.04.025
Popis: International audience; Adipose tissue secretes a variety of bioactive factors, which can regulate cardiomyocyte hypertrophy via reactive oxygen species (ROS). In the present study we investigated whether apelin affects ROS-dependent cardiac hypertrophy. In cardiomyocytes apelin inhibited the hypertrophic response to 5-HT and oxidative stress induced by 5-HT- or H(2)O(2) in a dose-dependent manner. These effects were concomitant to the increase in mRNA expression and activity of catalase. Chronic treatment of mice with apelin attenuated pressure-overload-induced left ventricular hypertrophy. The prevention of hypertrophy by apelin was associated with increased myocardial catalase activity and decreased plasma lipid hydroperoxide, as an index of oxidative stress. These results show that apelin behaves as a catalase activator and prevents cardiac ROS-dependent hypertrophy.
Databáze: OpenAIRE
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