Malignancy-induced lactic acidosis in adult lymphoma
| Autor: | Vaidyanathapuram S. Balakrishnan, Bertrand L. Jaber, Parikshit Duriseti, Nicolaos E. Madias, Yenny Moreno Vanegas |
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| Rok vydání: | 2020 |
| Předmět: |
Male
medicine.medical_specialty Lymphoma medicine.medical_treatment Alkalies Malignancy Gastroenterology Internal medicine Medicine Humans Acidosis Aged Chemotherapy business.industry General Medicine Middle Aged medicine.disease Warburg effect Pathophysiology Nephrology Anaerobic glycolysis Lactic acidosis Cancer cell Acidosis Lactic medicine.symptom business |
| Zdroj: | Clinical nephrology. 95(1) |
| ISSN: | 0301-0430 |
| Popis: | Malignancy-induced lactic acidosis (MILA), a rare paraneoplastic phenomenon, is mostly described with hematologic malignancies (lymphomas and leukemias) but has also been reported with solid tumors. It is a subset of type B lactic acidosis being mediated without evidence of tissue hypoperfusion. Lymphoma-induced lactic acidosis is often considered an oncologic emergency and is associated with an increased risk of mortality and poor prognosis. It has a complex pathophysiology centered in the "Warburg effect," i.e., the programming of cancer cells to depend on aerobic glycolysis for promotion of their proliferation and anabolic growth. The treatment of lymphoma-induced lactic acidosis is focused on prompt administration of chemotherapy. The role of alkali therapy in this setting is controversial and has limited proven benefit with a potential for worsening the lactic acidosis. If alkali therapy is used in the presence of severe acidemia to optimize cardiovascular status, it should be administered judiciously. |
| Databáze: | OpenAIRE |
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