Activated Carbon-Based System for the Disposal of Psychoactive Medications
Autor: | Ajay K. Banga, Yang Song, William Fowler, Mahima Manian, Andrew Korey |
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Jazyk: | angličtina |
Rok vydání: | 2016 |
Předmět: |
Drug
media_common.quotation_subject lcsh:RS1-441 Pharmaceutical Science 010501 environmental sciences Pharmacology 01 natural sciences Article lcsh:Pharmacy and materia medica 03 medical and health sciences psychoactive 0302 clinical medicine medicine activated carbon lorazepam diazepam 0105 earth and related environmental sciences media_common Active ingredient Waste management Chemistry Lorazepam buprenorphine adsorption deactivation desorption Leaching (metallurgy) 030217 neurology & neurosurgery Activated carbon medicine.drug Buprenorphine |
Zdroj: | Pharmaceutics; Volume 8; Issue 4; Pages: 31 Pharmaceutics, Vol 8, Iss 4, p 31 (2016) Pharmaceutics |
ISSN: | 1999-4923 |
DOI: | 10.3390/pharmaceutics8040031 |
Popis: | The misuse and improper disposal of psychoactive medications is a major safety and environmental concern. Hence, the proper disposal of these medications is critically important. A drug deactivation system which contains activated carbon offers a unique disposal method. In the present study, deactivation efficiency of this system was tested by using three model psychoactive drugs. HPLC validation was performed for each drug to ensure that the analytical method employed was suitable for its intended use. The method was found to be specific, accurate and precise for analyzing the drugs. The extent and rate of deactivation of the drugs was determined at several time points. After 28 days in the presence of activated carbon, the extent of leaching out of the drugs was evaluated. Deactivation started immediately after addition of the medications into the disposal pouches. Within 8 h, around 47%, 70% and 97% of diazepam, lorazepam and buprenorphine were adsorbed by the activated carbon, respectively. By the end of 28 days, over 99% of all drugs were deactivated. The desorption/leaching study showed that less than 1% of the active ingredients leached out from the activated carbon. Thus, this deactivation system can be successfully used for the disposal of psychoactive medications. |
Databáze: | OpenAIRE |
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