RAFT Emulsion Polymerization as a Platform to Generate Well-Defined Biocompatible Latex Nanoparticles
| Autor: | Matthias Hartlieb, Sébastien Perrier, Francis Lévi, Pratik Gurnani, Robert Dallmann, Helena Xandri-Monje, Carlos Sanchez-Cano, Alexander B. Cook, Kristin Abraham |
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| Přispěvatelé: | Bio-Organic Chemistry |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Male
Biodistribution Latex Polymers and Plastics Radical polymerization Size-exclusion chromatography Nanoparticle Emulsion polymerization Bioengineering 02 engineering and technology core–shell 010402 general chemistry 01 natural sciences Polymerization Biomaterials Mice Materials Testing Materials Chemistry Humans Latex/chemistry Animals QD biocompatible nanoparticles Chemistry reversible addition fragmentation chain transfer emulsion polymerization Chain transfer Raft 021001 nanoscience & nanotechnology 0104 chemical sciences Chemical engineering Nanoparticles tunable nanoparticles Emulsions Particle size Nanoparticles/chemistry Caco-2 Cells 0210 nano-technology Biotechnology |
| Zdroj: | Macromolecular Bioscience, 18(10):1800213. Wiley-VCH Verlag |
| ISSN: | 1616-5187 |
| DOI: | 10.1002/mabi.201800213 |
| Popis: | Current approaches to generate core–shell nanoparticles for biomedical applications are limited by factors such as synthetic scalability and circulatory desorption of cytotoxic surfactants. Developments in controlled radical polymerization, particularly in dispersed states, represent a promising method of overcoming these challenges. In this work, well‐defined PEGylated nanoparticles are synthesized using reversible addition fragmentation chain transfer emulsion polymerization to control particle size and surface composition and were further characterized with light scattering, electron microscopy, and size exclusion chromatography. Importantly, the nanoparticles are found to be tolerated both in vitro and in vivo, without the need for any purification after particle synthesis. Pharmacokinetic and biodistribution studies in mice, following intraperitoneal injection of the nanoparticles, reveal a long (>76 h) circulation time and accumulation in the liver. |
| Databáze: | OpenAIRE |
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