Peptide hydrogel with self-healing and redox-responsive properties

Autor:	Areetha D’Souza, Liam R. Marshall, Jennifer Yoon, Alona Kulesha, Dona I. U. Edirisinghe, Siddarth Chandrasekaran, Parth Rathee, Rajeev Prabhakar, Olga V. Makhlynets
Rok vydání:	2021
Předmět:	General Engineering General Materials Science
Zdroj:	Nano convergence. 9(1)
ISSN:	2196-5404
Popis:	We have rationally designed a peptide that assembles into a redox-responsive, antimicrobial metallohydrogel. The resulting self-healing material can be rapidly reduced by ascorbate under physiological conditions and demonstrates a remarkable 160-fold change in hydrogel stiffness upon reduction. We provide a computational model of the hydrogel, explaining why position of nitrogen in non-natural amino acid pyridyl-alanine results in drastically different gelation properties of peptides with metal ions. Given its antimicrobial and rheological properties, the newly designed hydrogel can be used for removable wound dressing application, addressing a major unmet need in clinical care.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ffe018e2b9d64e93e3986e4d0d27513 https://pubmed.ncbi.nlm.nih.gov/35478076 Zobrazit plný text záznamu Full text from SpringerLink