Determinants of skin sensitivity to solar irradiation
| Autor: | P. van 't Veer, Lilian B M Tijburg, W.A.A. Klöpping-Ketelaars, E. Boelsma, A.F.M. Kardinaal, G. van Poppel, A.A. Vink, W.M.R. Broekmans |
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| Přispěvatelé: | TNO Voeding |
| Jazyk: | angličtina |
| Rok vydání: | 2003 |
| Předmět: |
Male
Pathology Skin Neoplasms basal-cell carcinoma medicine.medical_treatment Physiology radiation exposure Skin Pigmentation alpha tocopherol clinical-trial human experiment Eye color statistical significance reflectometry dna-damage integumentary system quantitative analysis vitamin blood level adult cryptoxanthin aged beta-carotene nutrition classification risk factor Health UV-induced erythema Consumer Science & Intelligent Systems radiation dose medicine.medical_specialty radiation response phenotype vitamin-e solar radiation chemistry alpha-tocopherol Humans serum concentrations human VLAG Global Nutrition Wereldvoeding cholesterol Dose-Response Relationship Radiation medicine.disease Ascorbic acid Cross-Sectional Studies Erythema ascorbic-acid Skin cancer Minimal erythema dose dietary intake Nutrition and Disease skin tumor correlation analysis cholesterol blood level Medicine (miscellaneous) Ascorbic Acid Melanin chemistry.chemical_compound Voeding en Ziekte Skin beta carotene Nutrition and Dietetics skin cancer Eye Color Retinol article Middle Aged carotenoid melanin Phenotypical and nutritional determinants light-induced erythema zeaxanthin female ultraviolet irradiation hypothesis sunlight medicine.symptom retinol Vitamin ultraviolet radiation Skin melanin content Adolescent Ultraviolet Rays sex difference prevalence Physiological Sciences Biology volunteer hair color Sex Factors blood medicine xanthophyll controlled study alpha carotene Melanins skin carcinogenesis Vitamin E questionnaire disease association prediction skin sensitivity lycopene Carotenoids human tissue radiosensitivity |
| Zdroj: | European Journal of Clinical Nutrition 57 (2003) European Journal of Clinical Nutrition, 10, 57, 1222-1229 European Journal of Clinical Nutrition, 57, 1222-1229 |
| ISSN: | 0954-3007 |
| Popis: | Background: Acute effects of UV irradiation include UV-induced erythema. Sunlight plays an important role in the development of skin cancer. Several predictive factors of UV-induced erythema could also be predictive for skin cancer. Objective: Our objective was to quantitatively assess phenotypical and nutritional determinants of sensitivity to UV irradiation, as assessed by the minimal erythema dose (MED). Design: We conducted a cross-sectional study among 335 volunteers. Sensitivity to UV irradiation was established through assessment of the MED. Phenotypical determinants, including skin melanin content, hair color and iris color were determined by skin reflectance spectrometry, a subjective questionnaire and an objective classification system, respectively. Furthermore, dietary exposure was measured by carotenoids, vitamin C, retinol and alpha-tocopherol in serum. Results: Male subjects were found to be more sensitive to UV irradiation; that is, the MED was significantly lower compared to female subjects. Skin melanin content, which was positively associated with iris color in both sexes and with hair color in men, was the main phenotypical determinant of sensitivity to UV irradiation. No associations were found between serum carotenoids and MED in the total study group. Vitamin C was inversely associated with MED. However, associations between carotenoids concentrations and MED showed a positive trend in subjects with melanin values above and a negative trend in subjects below the median after adjustment for gender and total cholesterol. Conclusions: Skin melanin content and gender are important determinants of sensitivity to UV irradiation. No relation was found between serum carotenoids and MED in the total study group. The inverse association between vitamin C and MED was against our hypothesis. For the modifying effect of melanin on the association between carotenoids and MED, we do not have a clear biological explanation. |
| Databáze: | OpenAIRE |
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