In vitro cytogenetic assessment and comparison of vildagliptin and sitagliptin
| Autor: | Zülal Atlı Şekeroğlu, Ceren Börçek Kasurka, Mehmet Elbistan, Aysegul Atmaca |
|---|---|
| Přispěvatelé: | Ondokuz Mayıs Üniversitesi |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Mitotic index Proliferation index Clinical Biochemistry Biomedical Engineering Bioengineering Sister chromatid exchange Comparison Pharmacology 03 medical and health sciences 0302 clinical medicine medicine Sitagliptin Vildagliptin Cytotoxicity Chemistry Cell growth Cell Biology In vitro genotoxicity 030104 developmental biology Antidiabetic 030220 oncology & carcinogenesis Original Article Micronucleus Biotechnology medicine.drug |
| Zdroj: | Cytotechnology |
| Popis: | BORCEK KASURKA, CEREN/0000-0002-5772-9463 WOS: 000501172700003 PubMed: 31555935 Vildagliptin and sitagliptin are commonly used antidiabetic drugs. Chromosomal aberration (CA), sister chromatid exchange (SCE) and cytokinesis-block micronucleus (CBMN) assays were employed to assess and compare cytotoxic and genotoxic effects of these drugs. Peripheral lymphocytes were exposed to 125 mu g/ml, 250 mu g/ml and 500 mu g/ml of vildagliptin and 250 mu g/ml, 500 mu g/ml and 1000 mu g/ml of sitagliptin for 24 h and 48 h with and without exogenous metabolic activation. At the end of the study, it was determined that these drugs and their metabolites had no genotoxic effects on CA, SCE and CBMN. On the other hand, parallel to the increase in dose, vildagliptin showed weak cytotoxicity on the mitotic index, and depending on its increase in dose; sitagliptin caused potential cytotoxicity and cytostatic effect on the mitotic index, nuclear division index and proliferation index. Due to their cytotoxic and cytostatic potential, these drugs inhibit cell proliferation. Ondokuz Mayis UniversityOndokuz Mayis University This study was supported by Ondokuz Mayis University with PYO.TIP.1904-15.030 project numbers. We also thank Seval Kontas Yedier for her technical help. |
| Databáze: | OpenAIRE |
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