Multiparametric evaluation by simultaneous PET-MRI examination in patients with histologically proven laryngeal cancer
| Autor: | Carlo Cavaliere, Mario Covello, Massimo Mesolella, Marco Aiello, Emanuele Nicolai, Valeria Romeo, Elena Cantone, Brigida Iorio, Luigi Barbuto |
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| Přispěvatelé: | Cavaliere, Carlo, Romeo, Valeria, Aiello, Marco, Mesolella, Massimo, Iorio, Brigida, Barbuto, Luigi, Cantone, Elena, Nicolai, Emanuele, Covello, Mario |
| Rok vydání: | 2017 |
| Předmět: |
Male
Larynx medicine.medical_specialty PET-MRI Laryngeal cancer Imaging Head and neck surgery Multimodal Imaging 030218 nuclear medicine & medical imaging 03 medical and health sciences 0302 clinical medicine Fluorodeoxyglucose F18 medicine Humans Radiology Nuclear Medicine and imaging Radiation treatment planning Laryngeal Neoplasms Aged Observer Variation medicine.diagnostic_test business.industry Cancer Magnetic resonance imaging General Medicine Middle Aged Laryngeal Neoplasm medicine.disease Magnetic Resonance Imaging medicine.anatomical_structure Positron emission tomography Positron-Emission Tomography 030220 oncology & carcinogenesis Female Tomography Radiology Radiopharmaceuticals Nuclear medicine business Emission computed tomography |
| Zdroj: | European Journal of Radiology. 88:47-55 |
| ISSN: | 0720-048X |
| Popis: | Objectives To evaluate the relationship between metabolic 18Fluoro-Deoxyglucose-Positron Emission Tomography (18FDG/PET) and morpho-functional parameters derived by Magnetic Resonance Imaging (MRI) in patients with histologically proven laryngeal cancer. To assess the clinical impact of PET/MRI examination on patient's staging and treatment planning. Methods 16 patients with histologically proven laryngeal cancer were enrolled and underwent whole body PET/CT followed by a dedicated PET/MRI of the head/neck region. Data were separately evaluated by two blinded groups: metabolic (SUV and MTV), diffusion (ADC) and perfusion (K trans , V e , k ep and iAUC) maps were obtained by positioning regions of interest (ROIs). Tumoral local extension assessed on PET/MRI was compared to endoscopic findings. Results A good inter-observer agreement was found in anatomical location and local extension of PET/MRI lesions (Cohen's kappa 0.9). PET/CT SUV measures highly correlate with ones derived by PET/MRI (e.g., p=0.96 for measures on VOI). Significant correlations among metabolic, diffusion and perfusion parameters have been detected. PET/MRI had a relevant clinical impact, confirming endoscopic findings (6 cases), helping treatment planning (9 cases), and modifying endoscopic primary staging (1 case). Conclusions PET/MRI is useful for primary staging of laryngeal cancer, allowing simultaneous collection of metabolic and functional data and conditioning the therapeutic strategies. |
| Databáze: | OpenAIRE |
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