Headache: A striking prodromal and persistent symptom, predictive of COVID-19 clinical evolution

Autor:	Caronna, Edoardo, Ballvé, Alejandro, Llauradó, Arnau, Gallardo, Víctor J., Ariton, Diana María, Lallana, Sofia, López Maza, Samuel, Olivé Gadea, Marta, Quibus, Laura, Restrepo, Juan Luis, Rodrigo-Gisbert, Marc, Vilaseca, Andreu, Hernandez Gonzalez, Manuel, Martinez Gallo, Monica, Alpuente, Alicia, Torres-Ferrus, Marta, Pujol Borrell, Ricard, Alvárez Sabín, J.., Pozo-Rosich, Patricia, Universitat Autònoma de Barcelona. Departament de Medicina
Rok vydání:	2020
Předmět:	Adult Male medicine.medical_specialty 2019-20 coronavirus outbreak Coronavirus disease 2019 (COVID-19) Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Pneumonia Viral Prodromal Symptoms Betacoronavirus Internal medicine medicine Humans Prospective Studies Prospective cohort study Pandemics Aged Special Section Articles Inflammation loss of smell Headache epidemiology business.industry SARS-CoV-2 Loss of smell Headache COVID-19 General Medicine Middle Aged Prognosis Female Neurology (clinical) prognosis business Coronavirus Infections Biomarkers
Zdroj:	Cephalalgia Dipòsit Digital de Documents de la UAB Universitat Autònoma de Barcelona
ISSN:	1468-2982
Popis:	Objective To define headache characteristics and evolution in relation to COVID-19 and its inflammatory response. Methods This is a prospective study, comparing clinical data and inflammatory biomarkers of COVID-19 patients with and without headache, recruited at the Emergency Room. We compared baseline with 6-week follow-up to evaluate disease evolution. Results Of 130 patients, 74.6% (97/130) had headache. In all, 24.7% (24/97) of patients had severe pain with migraine-like features. Patients with headache had more anosmia/ageusia (54.6% vs. 18.2%; p Conclusions Headache associated with COVID-19 is a frequent symptom, predictive of a shorter COVID-19 clinical course. Disabling headache can persist after COVID-19 resolution. Pathophysiologically, its migraine-like features may reflect an activation of the trigeminovascular system by inflammation or direct involvement of SARS-CoV-2, a hypothesis supported by concomitant anosmia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ff78803c14585b179d78e810273b2c8 https://pubmed.ncbi.nlm.nih.gov/33146036 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
Nepřihlášeným uživatelům se plný text nezobrazuje	K zobrazení výsledku je třeba se přihlásit.