Interleukin-5 Is Essential for Vaccine-Mediated Immunity but Not Innate Resistance to a Filarial Parasite
| Autor: | Le Goff, L, Loke, P, Ali, H F, Taylor, D W, Allen, J E, Allen, Judith |
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| Jazyk: | angličtina |
| Rok vydání: | 2000 |
| Předmět: |
Male
Immunology Helminthiasis Biology Microbiology Mice Immune system Immunity medicine Animals Interleukin 5 Filarioidea Mice Knockout Vaccines medicine.disease biology.organism_classification Immunity Innate Filariasis Vaccination Mice Inbred C57BL Infectious Diseases Immunization biology.protein Parasitology Antibody Fungal and Parasitic Infections Interleukin-5 |
| Zdroj: | Le Goff, L, Loke, P, Ali, H F, Taylor, D W, Allen, J E & Allen, J 2000, ' Interleukin-5 is essential for vaccine-mediated immunity but not innate resistance to a filarial parasite ', Infection and Immunity, vol. 68, no. 5, pp. 2513-7 . https://doi.org/10.1128/IAI.68.5.2513-2517.2000 |
| Popis: | The study of protective immune mechanisms effective against filarial nematodes has been hampered by the inability of these important human pathogens to infect laboratory mice. Recently,Litomosoides sigmodontis, a natural parasite of rats, has been developed as a valuable model for the study of filarial infection. BALB/c mice are fully susceptible to infection withL. sigmodontisthird-stage larvae and develop patent infection. In contrast, mice on the C57BL background are resistant, and parasites undergo only a single molt and do not mature to adulthood. We used interleukin-5 (IL-5)-deficient mice on the C57BL/6 background to address the role of IL-5 and eosinophils in the innate resistance of C57BL/6 mice. We found no differences in parasite survival between IL-5-deficient and C57BL/6 mice. However, when these mice were used for the analysis of vaccine-mediated immunity, a critical role for IL-5 was elucidated. Mice genetically deficient in IL-5 were unable to generate a protective immune response when vaccinated with irradiated larvae, whereas C57BL/6 mice were fully protected from challenge infection. These studies help to clarify the highly controversial role of eosinophils in filarial infection. |
| Databáze: | OpenAIRE |
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