The enterovirus 71 epidemic in 2008—public health implications for Hong Kong
| Autor: | Peter K.C. Cheng, Edmond Ma, King Chun Chan, Shuk Kwan Chuang, Christine Wong |
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| Jazyk: | angličtina |
| Předmět: |
Male
Microbiology (medical) medicine.medical_specialty Epidemiology Notifiable disease Population Epidemic Herpangina Case fatality rate Enterovirus 71 medicine Enterovirus Infections Humans education Child Epidemics education.field_of_study Communicable disease biology business.industry Incidence (epidemiology) Incidence Infant General Medicine biology.organism_classification medicine.disease Enterovirus A Human Infectious Diseases Child Preschool Population Surveillance Immunology Hong Kong Emerging infection Female Public Health business Hand Foot and Mouth Disease Demography |
| Zdroj: | International Journal of Infectious Diseases. (9):e775-e780 |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2010.02.2265 |
| Popis: | Summary Objectives We compared the epidemiological, clinical and laboratory characteristics of enterovirus 71 (EV71) cases recorded in the epidemic year of 2008 with those of the past decade. Methods We estimated the annual incidence rates in the general population and in different age groups. We reviewed the clinical and epidemiological information of the cases. The complication and case fatality rates (CFR) were compared with the corresponding average rates for the period 1998–2007. The molecular strains of EV71 isolates were determined. Results The estimated annual incidence was 1.4/100 000 in the general population, with the highest incidence (27.9/100 000) reported among children aged under 5 years. The seasonal peak occurred from May to July. The majority (92.9%) presented with hand-foot-mouth disease (HFMD; 90.8%) or herpangina, and 11.2% had complications including meningitis or encephalitis (6.1%), pneumonia (3.1%), acute flaccid paralysis (1.0%), and shock (1.0%). The CFR was 1.0%. Nearly half (45.9%) of school-aged cases had concurrent HFMD outbreaks at their schools/institutions. There was no statistically significant difference in the complications rate and CFR when compared to those of the past decade. Molecular analysis showed that the majority were genogroup C4 strains, similar to the past circulating strains. Conclusions The cyclical high activity has had significant public health and social implications. To strengthen public health surveillance and control, EV71 infection was made a statutory notifiable disease in 2009. |
| Databáze: | OpenAIRE |
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