CACNA1C rs1006737 SNP increases the risk of essential hypertension in both Chinese Han and ethnic Russian people of Northeast Asia
| Autor: | Hao Zhang, Boris Pushkarev, Mingyu Cong, Ming Jin, Changchun Qiu, Keyong Zhang, Yuri Vitkovsky, Baiyu Jian, Ningning Wang, Jicheng Liu, Olga Bolshakova, Sandeep Shrestha, Yuyuan Mu, Jiexin Zhou |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Adult
Genetic Markers Male China Calcium Channels L-Type Chinese Han and ethnic Russian people Ethnic group Observational Study Essential hypertension Polymorphism Single Nucleotide White People CACNA1C gene Russia specific latitudes 03 medical and health sciences 0302 clinical medicine Asian People Risk Factors Genotype Humans Medicine genetics 030212 general & internal medicine Allele Risk factor Alleles business.industry Case-control study essential hypertension General Medicine Odds ratio Middle Aged medicine.disease Minor allele frequency biracial study Case-Control Studies 030220 oncology & carcinogenesis Female business Demography Research Article |
| Zdroj: | Medicine |
| ISSN: | 1536-5964 0025-7974 |
| Popis: | Voltage-gated Ca2+ channels play a key role in the regulation of arterial tone and blood pressure. The aim of this study was to determine whether the association of calcium voltage-gated channel subunit alpha1 C (CACNA1C) rs1006737 with essential hypertension (EH) exists in both Chinese Han and ethnic Russian populations of Northeast Asia. We used a case-control study of 2 ethnic groups in the same latitude geographical area to investigate the association between the susceptibility of EH and rs1006737 polymorphism. A total of 1512 EH patients and 1690 controls in Chinese Han people (Heilongjiang Provence, China), 250 EH patients, and 250 controls in ethnic Russian people (Chita, Russia), participated in this study. All participants were genotyped using the TaqMan SNP genotyping assay (Agena Company). Baseline characteristics and the minor allele frequencies of rs1006737 vary substantially among common Chinese Han and ethnic Russian people. Allele A was found to be a risk factor for EH in Chinese Han [(odds ratio) OR 1.705, (confidence interval) 95% CI: 1.332-2.182, P |
| Databáze: | OpenAIRE |
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