SECOND-TRIMESTER BIOCHEMICAL SCREENING
| Autor: | Joseph E. O'Brien, Elena Dvorin, Mark I. Evans, Harold Harrison, The-Hung Bui |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Genetics
medicine.medical_specialty business.industry Obstetrics and Gynecology Chromosome Disorders Public Policy Risk Assessment Multiple markers Predictive Value of Tests Pregnancy Second trimester Pregnancy Trimester Second Prenatal Diagnosis Pediatrics Perinatology and Child Health Humans Medicine Ethics Medical Female Neural Tube Defects Congenital disease business Intensive care medicine Algorithms Biomarkers |
| Zdroj: | Clinics in Perinatology. 28:289-301 |
| ISSN: | 0095-5108 |
| Popis: | The past years have seen considerable progress in the area of biochemical screening. Increasing data have now clearly shown the advantages of multiple markers, particularly beta-hCG over AFP alone. There continues to be considerable controversy over the best mathematic algorithm and which markers are best (e.g., beta-HCG, uE3, and so forth). There seems to be a plateau of detection frequencies at about 65% to 70% with current methodologies. Further work needs to be done, however, including some new approaches, if there is to be substantial improvement of screening sensitivity. The combination of biochemical with biophysical parameters as discussed elsewhere in this issue represents the next level of sophistication in the attempt to identify the highest proportion of abnormalities with the fewest false-positives. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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