Effect of a New International Reference Preparation for Proteins in Human Serum (Certified Reference Material 470) on Results of the College of American Pathologists Surveys for Plasma Proteins
| Autor: | Per Hyltoff Petersen, Anders Carlström, Thomas B. Ledue, A. Myron Johnson, John T. Whicher, Yoshihisa Itoh |
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| Rok vydání: | 2000 |
| Předmět: |
Quality Control
Pathology medicine.medical_specialty Certification Immunoglobulins Pathology and Forensic Medicine Albumins Statistics Humans Medicine Societies Medical Pathology Clinical Haptoglobins Reference preparation business.industry Transferrin Ceruloplasmin Reproducibility of Results Complement C4 Blood Proteins Complement C3 General Medicine Reference Standards Blood proteins Medical Laboratory Technology C-Reactive Protein Certified reference materials alpha 1-Antitrypsin business |
| Zdroj: | Archives of Pathology & Laboratory Medicine. 124:1496-1501 |
| ISSN: | 1543-2165 0003-9985 |
| DOI: | 10.5858/2000-124-1496-eoanir |
| Popis: | Objective.—To examine the impact of a new international reference preparation for serum proteins on the among-manufacturer variance in the College of American Pathologists Surveys. Data Source.—The results of the Surveys for the years 1993–1998, supplied by the College of American Pathologists. Data Extraction and Synthesis.—Mean values for manufacturers' assays were compared for each protein in the quality control samples. Results were separated by the reported reference material from which values for calibrators had been transferred. Standard statistical parameters (means, standard deviations, and coefficients of variation) were calculated from the reported means. Conclusions.—Among-manufacturer coefficients of variation have dropped significantly for most serum proteins since the introduction of the new reference material. Possible reasons for continued differences are discussed. |
| Databáze: | OpenAIRE |
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