Olfactory Dysfunctions and Decreased Nitric Oxide Production in the Brain of Human P301L Tau Transgenic Mice
| Autor: | Xue-lan Wang, Ruzhu Chen, Xiao-nan Zhu, Yang Hu, Wen-ting Ding |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
0301 basic medicine
Genetically modified mouse medicine.medical_specialty Neurology Tau protein Mice Transgenic tau Proteins Olfaction Nitric Oxide Synthase Type I Nitric Oxide Biochemistry Nitric oxide 03 medical and health sciences Cellular and Molecular Neuroscience chemistry.chemical_compound 0302 clinical medicine Discrimination Psychological Internal medicine medicine Animals Humans Olfactory memory Phosphorylation Maze Learning Nitrites Spatial Memory Nitrates biology Brain General Medicine Olfactory Bulb Olfactory bulb Smell 030104 developmental biology Endocrinology chemistry biology.protein Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Neurochemical research. 41(4) |
| ISSN: | 1573-6903 |
| Popis: | Different patterns of olfactory dysfunction have been found in both patients and mouse models of Alzheimer's Disease. However, the underlying mechanism of the dysfunction remained unknown. Deficits of nitric oxide production in brain can cause olfactory dysfunction by preventing the formation of olfactory memory. The aim of this study was to investigate the behavioral changes in olfaction and alterations in metabolites of nitric oxide, nitrate/nitrite concentration, in the brain of human P301L tau transgenic mice. The tau mice showed impairments in olfaction and increased abnormal phosphorylation of Tau protein at AT8 in different brain areas, especially in olfactory bulb. We now report that these olfactory deficits and Tau pathological changes were accompanied by decreased nitrate/nitrite concentration in the brain, especially in the olfactory bulb, and reduced expression of nNOS in the brain of tau mice. These findings provided evidence of olfactory dysfunctions correlated with decreased nitric oxide production in the brain of tau mice. |
| Databáze: | OpenAIRE |
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