Two new unusual monoterpene acid glycosides from Acacia cyclops with potential cytotoxic activity
| Autor: | Aymen Ben Nejma, Hichem Ben Jannet, Amira Jelassi, Jalloul Bouajila, Meriam Belaiba, Afifa Zardi-Bergaoui |
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| Rok vydání: | 2014 |
| Předmět: |
Monoterpene
Clinical Biochemistry Molecular Conformation Pharmaceutical Science Biochemistry Structure-Activity Relationship Glucosides Cell Line Tumor Drug Discovery Acacia cyclops medicine Cytotoxic T cell Humans Molecular Biology Cell Proliferation chemistry.chemical_classification biology Dose-Response Relationship Drug Chemistry Organic Chemistry Acacia Cancer Glycoside Fabaceae medicine.disease biology.organism_classification Antineoplastic Agents Phytogenic In vitro Phytochemical MCF-7 Cells Monoterpenes Molecular Medicine Drug Screening Assays Antitumor |
| Zdroj: | Bioorganicmedicinal chemistry letters. 24(16) |
| ISSN: | 1464-3405 |
| Popis: | A phytochemical investigation of the Tunisian plant Acacia cyclops pods led to the isolation of two new monoterpenoid glycosides, which have been designated Cyclopside 1 and Cyclopside 2. Their structures were elucidated on the basis of extensive spectroscopic procedures including IR, MS and 2D-NMR. The cytotoxic effect of the isolates was also evaluated in vitro against the human breast cancer (MCF-7) and ovarian cancer (OVAR) cell lines. Results showed that the highest cytotoxic activity (90.88%) was against MCF-7 cell line and was exhibited by the Cyclopside 1 at the concentration of 50 μg/mL. |
| Databáze: | OpenAIRE |
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