Overexpressed cyclo-oxygenase-2 in the background liver is associated with the clinical course of hepatitis C virus-related cirrhosis patients after curative surgery for hepatocellular carcinoma
| Autor: | Yasushi Rino, Yuji Yamamoto, Shoji Takemiya, Yoshiyasu Nakamura, Yukio Sugimasa, Makoto Akaike, Soichiro Morinaga, Shinichi Ohkawa, Kazuo Tarao, Kaoru Miyakawa |
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| Rok vydání: | 2007 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Carcinoma Hepatocellular Cirrhosis Hepatitis C virus Hepacivirus medicine.disease_cause Gastroenterology Disease-Free Survival Virus Flaviviridae Internal medicine Hepatectomy Humans Medicine Risk factor Aged Hepatology biology business.industry Liver Neoplasms Middle Aged Prognosis medicine.disease biology.organism_classification Hepatitis C digestive system diseases Up-Regulation Liver Cyclooxygenase 2 Hepatocellular carcinoma Immunohistochemistry Female business |
| Zdroj: | Journal of Gastroenterology and Hepatology. 22:1249-1255 |
| ISSN: | 1440-1746 0815-9319 |
| DOI: | 10.1111/j.1440-1746.2006.04367.x |
| Popis: | Background: The probable role of cyclo-oxygenase-2 (COX-2) in the development of hepatocellular carcinoma (HCC) in patients with chronic liver diseases has been accepted to be relevant. The purpose of the present study was to determine whether overexpressed COX-2 in the background liver affects the clinical course of hepatitis C virus (HCV)-related cirrhosis patients after curative surgery for HCC. Methods: Twenty-nine clinical stage I HCC patients with HCV-related cirrhosis, who underwent curative surgery, were enrolled in the present study (22 men and seven women, age range 53–73 years; follow-up period; range 22–159 months, median 61 months). The COX-2 expression in the cirrhotic liver was examined by immunohistochemistry using the avidin–biotin–peroxidase complex technique on paraffin-embedded formalin-fixed tissue. The COX-2 expression was scored, then correlated with monitored alanine aminotransferase (ALT) levels during the follow-up period after surgery, response to alternative therapy aiming to improve elevated ALT levels, and recurrence/survival after surgery. Results: The COX-2 expression scores were significantly higher in the high-ALT group than in the low-ALT group (Mann–Whitney, P = 0.010), and were significantly higher in non-responders to the alternative therapy than in responders (Mann–Whitney, P = 0.028). The higher COX-2 expression in the cirrhotic liver was the significant independent risk factor for residual liver recurrence (Cox multivariate analysis, P = 0.014), but not for survival. Conclusions: Overexpressed COX-2 in the background liver may play an important role in prolonged acceleration of necroinflammation, resistance to the alternative therapy, and recurrence/new development of HCC in HCV-related cirrhosis patients. |
| Databáze: | OpenAIRE |
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