Canalicular adenoma: report of five cases with ultrastructural observations
| Autor: | A. C. Smillie, M. D. McMillan, C.J. Smith |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
Capsular Invasion
Adenoma Male Cancer Research Pathology medicine.medical_specialty Cytoplasm Connective tissue Canalicular adenoma Biology Bone canaliculus Cytoplasmic Granules Endoplasmic Reticulum Epithelium Pathology and Forensic Medicine medicine Humans Aged Aged 80 and over Cell Nucleus Tight junction Cysts Cell Membrane Anatomy Middle Aged medicine.disease Mitochondria Actin Cytoskeleton medicine.anatomical_structure Intercellular Junctions Otorhinolaryngology Connective Tissue Lip Neoplasms Ultrastructure Periodontics Female Mouth Neoplasms Oral Surgery Ribosomes |
| Zdroj: | Journal of oral pathologymedicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology. 22(8) |
| ISSN: | 0904-2512 |
| Popis: | Canalicular adenomas from five patients were examined by light and electron microscopy. All patients were over 50 years of age; 4 of the lesions were from the upper lip, 4 were cystic, 2 showed capsular invasion and 1 was multifocal. Histopathologically there were epithelial duct-like or canalicular structures cut at various angles and epithelial islands surrounded by hyalinized and mucinous connective tissue that contained little collagen. Ultrastructurally the epithelial islands contained many small lumina and connective tissue islands. The characteristic epithelial cell was columnar or cuboidal, extended from the lumina to the connective tissue, had almost straight lateral cell boundaries with desmosomes that predominated near the lumina, and possessed gap junctions and a small number of tight junctions. Their main cytoplasmic constituents were ribosomes, mitochondria, rough-surfaced endoplasmic reticulum and microfilaments. These findings show that canalicular adenomas are truly monomorphic and support the concept that they are derived from the cells of excretory ducts. |
| Databáze: | OpenAIRE |
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