The transition from an aerobic to an anaerobic energy metabolism in transforming Schistosoma mansoni cercariae occurs exclusively in the head
| Autor: | Aloysius G.M. Tielens, Anja M.C. Horemans, S.G. van den Bergh |
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| Rok vydání: | 1991 |
| Předmět: |
Energy metabolism
chemistry.chemical_compound parasitic diseases Animals Anaerobiosis Pyruvates Pyruvate increased biology Transition (genetics) Temperature Water Anatomy Metabolism Schistosoma mansoni Carbon Dioxide biology.organism_classification Chromatography Ion Exchange Aerobiosis Culture Media Infectious Diseases Glucose chemistry Carbon dioxide Biophysics Lactates Animal Science and Zoology Parasitology Salts Energy Metabolism Anaerobic exercise Glycogen |
| Zdroj: | Parasitology. |
| ISSN: | 0031-1820 |
| Popis: | SUMMARYIt has been shown that in intact cercariae of Schistosoma mansoni in water, both head and tail had an identical, aerobic energy metabolism. As long as the environment was water, glucose was mainly degraded to carbon dioxide by both head and tail whether or not these two were still connected to each other. Transfer of intact cercariae into a simple salt medium supplemented with glucose resulted in a very rapid transition towards a more anaerobic energy metabolism: the production of lactate and pyruvate increased, whereas the production of carbon dioxide remained more or less constant. A concomitant rise in temperature to 37°C was not essential for this biochemical transition, but made it more pronounced. Experiments on isolated cercarial bodies and tails in a transforming medium demonstrated that the tails oxidized glucose to carbon dioxide, whereas bodies produced mainly pyruvate and lactate. The results showed that the metabolic transition towards a more anaerobic energy metabolism occurred only in the head and not in the tail of the cercariae. Loss of the tail was shown not to be a pre-requisite for this transition, nor did it by itself trigger a metabolic switch in the resulting cercarial body. |
| Databáze: | OpenAIRE |
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