Atypical presentation of Behçet’s disease with central nervous system involvement successfully treated with infliximab
| Autor: | G. Waldegg, R. Escher, B. Ruehe, U. Studer, Istvan Vajtai, Daniel Aeberli |
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| Rok vydání: | 2011 |
| Předmět: |
Adult
medicine.medical_specialty Biopsy Immunology Azathioprine Behcet's disease Drug Administration Schedule Hypesthesia Upper Extremity Lesion Rheumatology Central Nervous System Diseases Internal medicine medicine Humans Immunology and Allergy Trigeminal Nerve Drug Substitution Tumor Necrosis Factor-alpha business.industry Behcet Syndrome Remission Induction Headache Antibodies Monoclonal Sensory loss medicine.disease Immunohistochemistry Magnetic Resonance Imaging Dermatology Infliximab Surgery Treatment Outcome Female medicine.symptom business Complication Immunosuppressive Agents medicine.drug |
| Zdroj: | Studer, U; Ruehe, B; Waldegg, G; Vajtai, I; Escher, R; Aeberli, D (2012). Atypical presentation of Behçet's disease with central nervous system involvement successfully treated with infliximab. Rheumatology international, 32(5), pp. 1431-5. Berlin: Springer 10.1007/s00296-011-1915-x |
| ISSN: | 1437-160X 0172-8172 |
| Popis: | Central nervous system involvement is a rare and serious complication of Behçet's disease (BD). Herein, we describe a patient with an atypical central lesion, who experienced progressive hypesthesia of the right arm and sensory loss of the trigeminal nerve together with intense headache. A repeated biopsy was necessary to conclusively establish the diagnosis of BD. Therapy with infusions of infliximab led to a remarkable full remission. TNFα-blocking therapy was successfully replaced by azathioprine. The present well-illustrated case demonstrates the difficulty of establishing the diagnosis of BD with central nervous system involvement, the dramatic benefit of short given TNF-α-blocking agent, and the long-term remission with azathioprin. |
| Databáze: | OpenAIRE |
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