A 3‐dimensional‐printed left ventricle model incorporated into a mock circulatory loop to investigate hemodynamics inside a severely failing ventricle supported by a blood pump
| Autor: | Shengshou Hu, Jian-Feng Hou, Run-Jie Wei, Guang-Mao Liu |
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| Rok vydání: | 2020 |
| Předmět: |
Models
Anatomic medicine.medical_specialty Heart Ventricles 0206 medical engineering Biomedical Engineering Medicine (miscellaneous) Hemodynamics Aorta Thoracic Bioengineering 02 engineering and technology Blood stasis 030204 cardiovascular system & hematology Severity of Illness Index Biomaterials 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Heart Failure business.industry Models Cardiovascular Equipment Design General Medicine Blood flow medicine.disease 020601 biomedical engineering Thrombosis Blood pump medicine.anatomical_structure Ventricle Heart failure Printing Three-Dimensional Circulatory system Cardiology Heart-Assist Devices Tomography X-Ray Computed business |
| Zdroj: | Artificial Organs. 45:143-150 |
| ISSN: | 1525-1594 0160-564X |
| Popis: | Intraventricular blood stasis is a design consideration for continuous flow blood pumps and might contribute to adverse events such as thrombosis and ventricular suction. However, the blood flow inside left ventricles (LVs) supported by blood pumps is still unclear. In vitro experiments were conducted to imitate how the hydraulic performance of an axial blood pump affects the intraventricular blood flow of a severe heart failure patient, such as velocity distribution, vorticity, and standard deviation of velocity. In this study, a silicone model of the LV was constructed from the computed tomography data of one patient with heart failure and was 3D printed. Then, intraventricular flow was visualized by particle image velocimetry equipment within a mock circulation loop. The results showed that the axial blood pump suctions most of the blood in a severely failing LV, there was an altered flow status within the LV, and blood stasis appeared in the central region of the LV. Some blood may be suctioned from the aortic valve to the blood pump because the patient's native heart was severely failing. Blood stasis at the LV center may cause thrombosis in the LV. The vortex flow near the inner wall of the LV can thoroughly wash the left ventricular cavity. |
| Databáze: | OpenAIRE |
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