Effect of omega-3 fatty acids and simvastatin on hemostatic risk factors and postprandial hyperlipemia in patients with combined hyperlipemia
| Autor: | Hugo Nilsen, Per Morten Sandset, John-Bjarne Hansen, Arne Nordøy, Kaare H. Bønaa |
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| Rok vydání: | 2000 |
| Předmět: |
Adult
Blood Glucose Male medicine.medical_specialty Simvastatin Diet therapy medicine.medical_treatment Lipoproteins Hyperlipidemias Factor VIIa Eating Double-Blind Method Risk Factors Internal medicine Fatty Acids Omega-3 medicine Humans In patient Hypolipidemic Agents chemistry.chemical_classification Chemotherapy Hemostasis biology business.industry Thrombosis Middle Aged medicine.disease Dietary Fats Enzyme Endocrinology Postprandial chemistry Enzyme inhibitor biology.protein Female Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Arteriosclerosis, thrombosis, and vascular biology. 20(1) |
| ISSN: | 1079-5642 |
| Popis: | Abstract —Patients with combined hyperlipemia have lipid abnormalities associated with an increased tendency to develop atherosclerosis and thrombosis. This tendency may be accelerated during postprandial hyperlipemia. In the present double-blind parallel study, 41 patients with combined hyperlipemia and serum triacylglycerols between 2.0 and 15.0 mmol/L and serum total cholesterol >5.3 mmol/L at the end of a 3-month dietary run-in period were treated with simvastatin at 20 mg/d for at least 10 weeks; patients were then randomized into 2 groups receiving simvastatin+ω-3 fatty acids at 3.36 g/d or placebo (corn oil) for an additional 5 weeks. Hemostatic variables that have been associated with increased thrombotic tendency were evaluated with subjects in the fasting state and during postprandial hyperlipemia before and after combined treatment. Supplementation of ω-3 fatty acid reduced tissue factor pathway inhibitor antigen ( P P |
| Databáze: | OpenAIRE |
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