Levels of uric acid in erectile dysfunction of different aetiology

Autor:	L. Vaccalluzzo, Massimiliano Marco Corsi Romanelli, Nadia Papini, Luca Massaccesi, C.A.L. Damele, Raffaele Pezzilli, Alessandra Barassi, Elena Dozio, Gian Vico Melzi d’Eril, Marco Di Dario, Giovanni M. Colpi, Giancarlo Goi
Rok vydání:	2018
Předmět:	Adult Male medicine.medical_specialty Common disease 030232 urology & nephrology Gastroenterology Impotence Vasculogenic 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Proper function Internal medicine Surveys and Questionnaires medicine Humans Endothelial dysfunction Ultrasonography Doppler Color 030219 obstetrics & reproductive medicine business.industry Penile Erection Middle Aged medicine.disease Uric Acid Erectile dysfunction chemistry Case-Control Studies Etiology Uric acid Endothelium Vascular Geriatrics and Gerontology business
Zdroj:	The aging male : the official journal of the International Society for the Study of the Aging Male. 21(3)
ISSN:	1473-0790
Popis:	Erectile dysfunction is a common disease characterized by endothelial dysfunction. The aetiology of ED is often multifactorial but evidence is being accumulated in favor of the proper function of the vascular endothelium that is essential to achieving and maintaining penile erection. Uric acid itself causes endothelial dysfunction via decreased nitric oxide production. This study aims to evaluate the serum uric acid (SUA) levels in 180 ED patients, diagnosed with the International Index of Erectile Function-5 (IIEF-5) and 30 non-ED control. Serum uric acid was analyzed with a commercially available kit using ModularEVO (Roche, Monza, Italy). Within-assay and between-assay variations were 3.0% and 6.0%, respectively. Out of the ED patients, 85 were classified as arteriogenic (A-ED) and 95 as non-arteriogenic (NA-ED) with penile-echo-color-Doppler. Uric acid levels (median and range in mg/dL) in A-ED patients (5.8, 4.3-7.5) were significantly higher (p .001) than in NA-ED patients (4.4, 2.6-5.9) and in control group (4.6, 3.1-7.2). There was a significant difference (p .001) between uric acid levels in patients with mild A-ED (IIEF-5 16-20) and severe/complete A-ED (IIEF-5 ≤ 10) that were 5.4 (range 4.3-6.5) mg/dL and 6.8 (range 6.4-7.2) mg/dL, respectively. There was no difference between the levels of uric acid in patients with different degree of NA-ED. Our findings reveal that SUA is a marker of ED but only of ED of arteriogenic aetiology.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe5677b445d8d6e7586f928e0e40cc3 https://pubmed.ncbi.nlm.nih.gov/29327639 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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