Prognostic value of metabolic tumor volume and total lesion glycolysis from 18F-FDG PET/CT in lymph node metastases and risk stratification of endometrial carcinoma
| Autor: | Mu Hua Cheng, Luping Qin, Dou Dou Liu, Fangyu Peng, Xiaomao Li, Liang-Jun Xie, Jianfang Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
medicine.medical_specialty Tumor Volume Standardized uptake value Risk Assessment 03 medical and health sciences 0302 clinical medicine Uterine Corpus Fluorodeoxyglucose F18 Positron Emission Tomography Computed Tomography parasitic diseases medicine Carcinoma Humans Pathological Lymph node Aged Retrospective Studies Aged 80 and over 030219 obstetrics & reproductive medicine medicine.diagnostic_test business.industry Obstetrics and Gynecology General Medicine Metabolic tumor volume Middle Aged medicine.disease Prognosis Lymphovascular Endometrial Neoplasms Tumor Burden Total lesion glycolysis medicine.anatomical_structure Metabolism Oncology ROC Curve Positron emission tomography 030220 oncology & carcinogenesis Lymphatic Metastasis Lymph Node Excision Original Article Lymphatic Metastases Female Radiology Radiopharmaceuticals business Endometrial Carcinoma Glycolysis |
| Zdroj: | Journal of Gynecologic Oncology |
| ISSN: | 2005-0399 2005-0380 |
| Popis: | OBJECTIVE To investigate the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG), measured by preoperative ¹⁸F-fluorodeoxyglucose positron emission tomography/computed tomography (¹⁸F-FDG PET/CT), in risk stratification of patients with endometrial carcinoma (EC). METHODS The patients with pathological diagnosis of EC who underwent preoperative ¹⁸F-FDG PET/CT imaging were retrospectively selected for analysis of the prognostic values of PET parameters in risk classification and lymph node metastases (LNMs). Receiver-operating-characteristic analysis was used to analyze the correlation of PET parameters cutoff values with deep myometrial invasion (MI), lymphovascular space involvement and LNM for prognostic values in risk stratification. RESULTS The sensitivity, specificity, positive predictive value, negative predictive value and accuracy for detection of LNM are 83.3%, 99.7%, 90.9%, 99.5% and 99.2%, respectively. The MTV and TLG of primary lesion of EC in the patients with LNM are notably higher than those in patients without LNM, p |
| Databáze: | OpenAIRE |
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