The myosin activator omecamtiv mecarbil improves wall stress in a rat model of chronic aortic regurgitation
| Autor: | Constantin Stefanidis, Kathleen Mc Entee, Bachar Ghassan El Oumeiri, G. Hubesch, Philippe van de Borne, Pascale Jespers, Antoine Herpain, Filippo Annoni, Frédéric Vanden Eynden |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Cardiac function curve medicine.medical_specialty Cardiac output Cardiotonic Agents Systole Physiology Heart Ventricles overload Aortic Valve Insufficiency Diastole Afterload Physiology (medical) Internal medicine medicine QP1-981 Animals Urea Rats Wistar Infusions Intravenous business.industry Stroke Volume Original Articles Stroke volume aortic regurgitation Rats Preload Omecamtiv mecarbil wall stress medicine.anatomical_structure Ventricle omecamtiv mecarbil Cardiology Original Article business |
| Zdroj: | Physiological Reports Physiological Reports, Vol 9, Iss 16, Pp n/a-n/a (2021) |
| ISSN: | 2051-817X |
| DOI: | 10.14814/phy2.14988 |
| Popis: | In patients with chronic aortic regurgitation (AR), excessive preload and afterload increase left ventricle wall stress, leading to left ventricular systolic dysfunction. Thus, the objective of the present study was to evaluate the effects of the myosin activator omecamtiv mecarbil (OM) on left ventricle wall stress in an experimental rat model of severe chronic AR. Forty adult male Wistar rats were randomized into two experimental groups: induction of AR (acute phase) by retrograde puncture (n = 34) or a sham intervention (n = 6). Rats that survived the acute phase (n = 18) were randomized into an OM group (n = 8) or a placebo group (n = 10). Equal volumes of OM (1.2 mg/kg/h) or placebo (0.9% NaCl) were continuously infused into the femoral vein over 30 min. OM significantly decreased end‐systolic and end‐diastolic and maximum wall stress in this experimental rat model of chronic severe AR (p Aortic regurgitation increase left ventricle wall stress, the objective of this study is to evaluate the effects of omecamtiv mecarbil on left ventricle wall stress. |
| Databáze: | OpenAIRE |
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