Gastrointestinal tolerance to an inulin-rich soluble roasted chicory extract after consumption in healthy subjects
| Autor: | Myriam Janssens, Bernard Flourié, Christophe Ripoll, Olivier Hermand, Sophie Megnien |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male medicine.medical_specialty Sucrose Adolescent Gastrointestinal Diseases Endocrinology Diabetes and Metabolism medicine.medical_treatment Inulin Gastroenterology Coffee Chicory chemistry.chemical_compound Feces Young Adult Bloating Double-Blind Method Dietary Sucrose Reference Values Internal medicine medicine Ingestion Flatulence Humans Food science Aged Nutrition and Dietetics business.industry Plant Extracts Prebiotic Middle Aged Indigestion Crossover study Abdominal Pain chemistry Female medicine.symptom business |
| Zdroj: | Nutrition (Burbank, Los Angeles County, Calif.). 26(7-8) |
| ISSN: | 1873-1244 |
| Popis: | Objectives We aimed to assess in healthy subjects 1) the effect of two doses of a new naturally inulin-rich soluble chicory extract (IRSCE) on overall gastrointestinal discomfort after short-term ingestion and 2) the effect on gastrointestinal symptoms of long-term consumption of IRSCE administered at a dose compatible with its future commercial use. Methods First, the effect of IRSCE was assessed on overall gastrointestinal discomfort in a double-blind, crossover study where 18 subjects received in a randomized order a morning coffee drink including 10 g of sucrose alone (control period) or with IRSCE at two doses (8.9 and 14.0 g containing 5.0 and 7.8 g of inulin, respectively) during three consecutive 6-d periods. Second, 35 subjects were followed during a randomized, double-blind protocol where they were asked to take twice a day an instant coffee drink containing IRSCE (8.1 g/d containing inulin 5.0 g/d) or sucrose 8.1 g/d during 4 wk. The effects of the treatment on flatulence, bloating, abdominal pain, stool consistency, and number were recorded. Results In the first study a significant slight increase (P = 0.05) in overall abdominal discomfort was observed with the morning coffee drink containing 7.8 g of inulin after 1 wk of consumption. In the second study, no significant differences between the IRSCE and placebo groups were evidenced with respect to gastrointestinal symptoms during the consumption period. Conclusion Short- and long-term consumptions of IRSCE, given at a daily dose containing 5 g of inulin, are well tolerated by healthy subjects. |
| Databáze: | OpenAIRE |
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