New electron microscopic findings in a case of multicentric reticulohistiocytosis. Long spacing collagen inclusions
| Autor: | M Fortier-Beaulieu, X Le Loët, M. C. Boullie, P. Lauret, E. Thomine, Hemet J |
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| Rok vydání: | 1993 |
| Předmět: |
Pathology
medicine.medical_specialty Histiocytosis Non-Langerhans-Cell business.industry Long spacing Multicentric reticulohistiocytosis Dermatology General Medicine medicine.disease Skin Diseases Pathology and Forensic Medicine medicine Type VI collagen Humans Female Collagen business Electron microscopic Histiocyte Aged Skin |
| Zdroj: | The American Journal of dermatopathology. 15(6) |
| ISSN: | 0193-1091 |
| Popis: | The case of a 68-year-old woman with polyarthropathy and skin nodules is presented. Histologic findings of histiocytes with ground-glass cytoplasm favored the diagnosis of multicentric reticulohistiocytosis. In this article we report new electron microscopic findings of intra- and extracytoplasmic long spacing collagen (type VI). Type VI collagen inclusions are usually found in lymphohistiocytic neoplasms. We believe our findings support the concept of a proliferative rather than inflammatory etiology for multicentric reticulohistiocytosis. It may also give support for the argument of production of collagen by the histiocytic cells of multicentric reticulohistiocytosis. |
| Databáze: | OpenAIRE |
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