Study of chromosome 12 copy number in breast cancer using fluorescence in situ hybridization
| Autor: | William Taylor, Mangala Samy, Nader Bassily, Stephen Brown, Ci-Lin Sun, Kirby I. Bland, Hon Fong L. Mark |
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| Rok vydání: | 1999 |
| Předmět: |
Cancer Research
Aneuploidy Breast Neoplasms Chromosome Disorders Trisomy Biology Breast cancer Genetics medicine Humans Molecular Biology Chromosome 12 In Situ Hybridization Fluorescence Neoplasm Staging Chromosome Aberrations Polysomy Chromosomes Human Pair 12 medicine.diagnostic_test Carcinoma Ductal Breast medicine.disease Chromosome 17 (human) Cancer research Female Ploidy Fluorescence in situ hybridization |
| Zdroj: | Cancer genetics and cytogenetics. 108(1) |
| ISSN: | 0165-4608 |
| Popis: | Trisomy 12 is the most frequent numerical chromosomal abnormality reported in chronic lymphocytic leukemia (CLL). Its significance in other cancers, however, has not been extensively investigated until recently. Less than 20 cases of polysomy for chromosome 12 have been studied thus far. The most recent data in the literature suggest that gain of chromosome 12 may be a recurrent and sometimes early event in breast carcinogenesis. To test the hypothesis that a subset of breast cancer may be characterized by chromosome 12 trisomy, we conducted a retrospective study of 40 specimens. Of these, ten were stage I, ten were stage II, ten were stage III, and ten were stage IV. Out of the total sample, 12 cases (30%) were found to be presumably trisomic, if a conservative cutoff point of greater than or equal to 15% cells with three signals is adopted. Furthermore, some, but not all, of the 12 cases were found to be likely triploid, when data from a control chromosome 17 probe were taken into account. Thus, our data support the hypothesis that a subset of breast cancer exists which is characterized by an abnormal copy of chromosome 12, in either a diploid or a triploid background. |
| Databáze: | OpenAIRE |
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