Genetic analysis of chromosome 2 in type 1 diabetes: analysis of putative loci IDDM7, IDDM12, and IDDM13 and candidate genes NRAMP1 and IA-2 and the interleukin-1 gene cluster. IMDIAB Group
| Autor: | Constantin Ionesco-Tirgoviste, Amanda Wilson, Marilyn E. Merriman, Cecile Julier, John A. Todd, Lorenza Nisticò, Raffaella Buzzetti, Paolo Pozzilli, Eva Tuomilehto-Wolf, Emanuele Bosi, Flemming Pociot, Laura Esposito, C Muxworthy, Marc Delepine, Natasha J. Hill, Maurizio Ferrari, Jørn Nerup, Francesco Cucca, Stephen C. Bain, Jaakko Tuomilehto, L E Pritchard |
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| Rok vydání: | 1998 |
| Předmět: |
Genetic Linkage
Endocrinology Diabetes and Metabolism Denmark Locus (genetics) Biology Chromosome 15 Genetic linkage Internal Medicine Homologous chromosome Humans Finland Genetics Romania Chromosome United Kingdom United States Chromosome 17 (human) Diabetes Mellitus Type 1 Italy Chromosomes Human Pair 2 Multigene Family France Chromosome 21 Chromosome 22 Interleukin-1 Microsatellite Repeats |
| Zdroj: | Diabetes. 47(11) |
| ISSN: | 0012-1797 |
| Popis: | In the spontaneous mouse model of type 1 diabetes, the nonobese (NOD) strain, a type 1 diabetes locus, Idd5 , has been mapped to chromosome 1. Because mouse chromosome 1 shares a homologous 33-cM region between the genes col3a1 and col6a3 with human chromosome 2q31–q35 (data shown at http://www.ncbi.nlm.nih.gov/Omim/Homology/), several groups have searched chromosome 2 for loci affecting human type 1 diabetes. Previous studies have provided evidence for at least three type 1 diabetes loci ( IDDM7 , IDDM12 , and IDDM13 ) within a 23-cM region of chromosome 2q31–q35. We have now evaluated linkage on chromosome 2, by multipoint analysis using Mapmaker/Sibs, of 34 microsatellite markers and an interleukin-1 (IL-1) Taq I polymorphism in 352 U.K. families. |
| Databáze: | OpenAIRE |
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