New N-substituted 7-aminocephalosporanic acid derivatives as potential agents against Streptococcus pneumoniae. Synthesis and in vitro activity
| Autor: | Aldo Balsamo, Federico Calvani, Silvia Barontini, Armando Rossello, Marco Macchia, Enza Di Modugno, Antonio Felici, Daniela Gentili |
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| Rok vydání: | 1999 |
| Předmět: |
Staphylococcus aureus
medicine.drug_class Streptococcus pyogenes Gram-positive bacteria Clinical Biochemistry Antibiotics Cephalosporin Pharmaceutical Science Microbial Sensitivity Tests Biochemistry Chemical synthesis Microbiology Structure-Activity Relationship Drug Discovery medicine Molecular Biology Antibacterial agent biology Chemistry Organic Chemistry Antimicrobial biology.organism_classification Anti-Bacterial Agents Cephalosporins Streptococcus pneumoniae Molecular Medicine Antibacterial activity Bacteria |
| Zdroj: | Bioorganicmedicinal chemistry letters. 9(7) |
| ISSN: | 0960-894X |
| Popis: | The synthesis and the antimicrobial properties of a new series of cephalosporinic beta-lactam antibiotics is described. The data reported in the present paper show the potential of this type of substituted cephalosporins as new anti Gram-positive antibiotic drugs. In fact, all compounds tested showed a good in vitro antibacterial activity against the most relevant Gram-positive pathogens including resistant species that currently represent unmet medical need. On the contrary, the new synthesized compounds were found to be completely devoid of any activity on Gram-negative bacteria up to a concentration of the single agent of 128 microg/ml. |
| Databáze: | OpenAIRE |
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