Cellular multitasking: the dual role of human Cu-ATPases in cofactor delivery and intracellular copper balance
| Autor: | Vesna Zuzel, Arnab Gupta, Jason L. Burkhead, Svetlana Lutsenko |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Cytoplasm
Protein Conformation ATPase ATP7A Biophysics Intracellular Space Biology Biochemistry Article ATOX1 Fungal Proteins Animals Humans Molecular Biology Cation Transport Proteins Secretory pathway Phylogeny Plant Proteins Adenosine Triphosphatases Fungal protein Ion Transport Cell biology Copper-Transporting ATPases Chaperone (protein) P-type ATPase biology.protein Intracellular Copper |
| Zdroj: | Archives of biochemistry and biophysics. 476(1) |
| ISSN: | 1096-0384 |
| Popis: | The human copper-transporting ATPases (Cu-ATPases) are essential for dietary copper uptake, normal development and function of the CNS, and regulation of copper homeostasis in the body. In a cell, Cu-ATPases maintain the intracellular concentration of copper by transporting copper into intracellular exocytic vesicles. In addition, these P-type ATPases mediate delivery of copper to copper-dependent enzymes in the secretory pathway and in specialized cell compartments such as secretory granules or melanosomes. The multiple functions of human Cu-ATPase necessitate complex regulation of these transporters that is mediated through the presence of regulatory domains in their structure, posttranslational modification and intracellular trafficking, as well as interactions with the copper chaperone Atox1 and other regulatory molecules. In this review, we summarize the current information on the function and regulatory mechanisms acting on human Cu-ATPases ATP7A and ATP7B. Brief comparison with the Cu-ATPase orthologues from other species is included. |
| Databáze: | OpenAIRE |
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