Treating with besifloxacin for acute bacterial conjunctivitis: a Meta-analysis
| Autor: | Xin-Yi Gao, Jun-Jie Wang, Shan-Shuang Du, Hong-Zhuo Li |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Bacterial Conjunctivitis
medicine.medical_specialty business.industry acute bacterial conjunctivitis Besifloxacin Placebo Gatifloxacin law.invention meta-analysis Ophthalmology besifloxacin Randomized controlled trial lcsh:Ophthalmology law Moxifloxacin lcsh:RE1-994 Internal medicine Meta-analysis randomized controlled trials medicine business Adverse effect medicine.drug |
| Zdroj: | International Journal of Ophthalmology, Vol 12, Iss 12, Pp 1898-1907 (2019) |
| ISSN: | 2227-4898 2222-3959 |
| Popis: | Aim To evaluate the relative efficacy and safety of besifloxacin for treatment of acute bacterial conjunctivitis. Methods A comprehensive search in PubMed, EMBASE Web of Science, Cochrane Central Database and CNKI was undertaken for randomized controlled trials (RCTs) comparing besifloxacin with other treatments or placebo. The primary outcome measures were clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, and bacterial eradication rates of different kinds of pathogens. Safety outcomes were the number of adverse effects (AEs). The final search was performed on August 2018. Results Six RCTs were included. Four studies compared the efficacy and safety of besifloxacin with placebo, 1 study compared besifloxacin with moxifloxacin, and 1 study compared besifloxacin with gatifloxacin. A total of 2780 patients met the inclusion criteria. Besifloxacin presented higher efficacy and safety than did placebo in clinical resolution, rates of bacterial eradication, individual clinical outcomes, cure rates, bacterial eradication rates of different kinds of pathogens and the number of AEs. There was no significant difference between besifloxacin and moxifloxacin or gatifloxacin in the comparison items mentioned above. Conclusion Besifloxacin is highly effective and safe for treatment of acute bacterial conjunctivitis. Further comparative trials regarding the effect of besifloxacin for treatment of acute bacterial conjunctivitis will aid in treatment decisions. |
| Databáze: | OpenAIRE |
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