The Cj0588 protein is a Campylobacter jejuni RNA methyltransferase
| Autor: | Danuta Klimuszko, Bartłomiej Taciak, Agnieszka Sałamaszyńska-Guz, Agnieszka Kwiatek |
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| Rok vydání: | 2014 |
| Předmět: |
Models
Molecular Protein family Protein Conformation Molecular Sequence Data 5.8S ribosomal RNA Biophysics Biology Methylation Biochemistry Ribosome Campylobacter jejuni Bacterial Proteins Drug Resistance Bacterial Amino Acid Sequence Capreomycin Molecular Biology 50S Genetics Sequence Homology Amino Acid Virulence RNA Methyltransferases Cell Biology Ribosomal RNA biology.organism_classification RNA Bacterial Genes Bacterial RNA Ribosomal Polyribosomes |
| Zdroj: | Biochemical and Biophysical Research Communications. 448:298-302 |
| ISSN: | 0006-291X |
| DOI: | 10.1016/j.bbrc.2014.04.104 |
| Popis: | TlyA proteins belong to 2′-O-methyltransferases. Methylation is a common posttranscriptional RNA modification. The Campylobacter jejuni Cj0588 protein belongs to the TlyAI protein family and is a rRNA methyltransferase. Methylation of ribosomal RNA catalyzed by Cj0588 appears to have an impact on the biology of the cell. Presence of the cj0588 gene in bacteria appears to be important for ribosome stability and virulence properties. Absence of the Cj0588 protein causes accumulation of the 50S ribosomal subunits, reduction in the amount of functional 70S ribosomes and confers increase resistance to capreomycin. |
| Databáze: | OpenAIRE |
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