Mean Oxygen Saturation during Sleep Is Related to Specific Brain Atrophy Pattern
| Autor: | Peter Vollenweider, Ferath Kherif, Pedro Marques-Vidal, José Haba-Rubio, Camila Hirotsu, Antoine Lutti, Cristina Ramponi, N. A. Marchi, Bogdan Draganski, Martin Preisig, Raphael Heinzer |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Adult
Male Sleep Wake Disorders 0301 basic medicine medicine.medical_specialty Polysomnography Population Hypoxemia Cohort Studies Angular gyrus 03 medical and health sciences Sleep Apnea Syndromes 0302 clinical medicine Supramarginal gyrus Internal medicine medicine Humans Cognitive decline Hypoxia education Aged Oxygen saturation (medicine) Aged 80 and over Cerebral Cortex education.field_of_study medicine.diagnostic_test business.industry Respiration Brain Middle Aged Magnetic Resonance Imaging Oxygen 030104 developmental biology Neurology Brain size Cardiology Female Neurology (clinical) Atrophy medicine.symptom Sleep business 030217 neurology & neurosurgery |
| Zdroj: | Annals of Neurology |
| ISSN: | 1531-8249 0364-5134 |
| Popis: | OBJECTIVE There is much controversy about the neurobiological mechanisms underlying the effects of sleep-disordered breathing on the brain. The aim of this study was to investigate the association between markers of sleep-related hypoxemia and brain anatomy. METHODS We used data from a large-scale cohort from the general population (n = 775, 50.6% males, age range = 45-86 years, mean age = 60.3 ± 9.9) that underwent full polysomnography and brain magnetic resonance imaging to correlate respiratory variables with regional brain volume estimates. RESULTS After adjusting for age, gender, and cardiovascular risk factors, only mean oxygen saturation during sleep was associated with bilateral volume of hippocampus (right: p = 0.001; left: p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Plný text