Aurantimycins, new depsipeptide antibiotics from Streptomyces aurantiacus IMET 43917. Production, isolation, structure elucidation, and biological activity
| Autor: | Schlegel Rolf, Michael Ritzau, Udo Gräfe, Wolfgang Ihn, Albert Härtl, Werner F. Fleck, W. Gutsche, Klausjürgen Dornberger, C. Stengel, E. F. Paulus |
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| Rok vydání: | 1995 |
| Předmět: |
Magnetic Resonance Spectroscopy
Stereochemistry Chemical structure Spectrometry Mass Fast Atom Bombardment Cell Line Mice X-Ray Diffraction Drug Discovery Animals Mycelium Antibacterial agent Pharmacology Depsipeptide Streptomyces aurantiacus biology Molecular Structure Cytotoxins Fast atom bombardment Fibroblasts biology.organism_classification Streptomyces Anti-Bacterial Agents Heteronuclear molecule Biochemistry Peptides Bacteria |
| Zdroj: | The Journal of antibiotics. 48(2) |
| ISSN: | 0021-8820 |
| Popis: | Aurantimycins A (1), B (2) and C (3) were isolated from the mycelium of Streptomyces aurantiacus JA 4570 as new representatives of the azinothricin group of hexadepsipeptide antibiotics. Their structures were settled by X-ray diffraction analysis of crystalline aurantimycin A (1), high field homo- and heteronuclear 2D NMR experiments, high-resolution mass spectrometry and amino acid analysis. Aurantimycins are characterized by a new side chain containing fourteen carbon atoms. They display strong activity against Gram-positive bacteria and cytotoxic effects against L-929 mouse fibroblast cells. |
| Databáze: | OpenAIRE |
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