Synthesis, Molecular Docking and Evaluation of 1,3,4‐Oxadiazole‐Isobenzofuran Hybrids as Antimicrobial and Anticancer Agents
| Autor: | Swarnagowri Nayak, Santosh L. Gaonkar, Druti Hazra, Kiran Chawla, Gangadhar Hari, K. S. R. Pai, Bharath Raja Guru, Sushruta S. Hakimane |
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| Rok vydání: | 2022 |
| Předmět: |
Oxadiazoles
Staphylococcus aureus Molecular Structure Antineoplastic Agents Bioengineering General Chemistry General Medicine Biochemistry Anti-Bacterial Agents Molecular Docking Simulation Structure-Activity Relationship Anti-Infective Agents Spectroscopy Fourier Transform Infrared Escherichia coli Humans Molecular Medicine Drug Screening Assays Antitumor Molecular Biology Cell Proliferation |
| Zdroj: | Chemistry & Biodiversity. 19 |
| ISSN: | 1612-1880 1612-1872 |
| DOI: | 10.1002/cbdv.202100956 |
| Popis: | In drug discovery, the hybridization of bioactive pharmacophores is a powerful tool for targeting enzymes involved in cancer and microbial cell growth. A combination of 1,3,4-oxadiazole and isobenzofuran may improve the antitumor and antimicrobial properties of the hybrid molecules. A series of hybrid molecules having 1,3,4-oxadiazole and isobenzofuran were synthesized and structural characterization was done by FT-IR |
| Databáze: | OpenAIRE |
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