Perinatal Outcomes of Singleton Live Births Following Preimplantation Genetic Testing for Chromosomal Structural Rearrangements in Single Frozen-Thawed Blastocyst Transfer Cycles: a Retrospective Cohort Study
| Autor: | Rujing Yang, Ruowen Zu, Shiyu Ran, Wei Zheng, Chen Yang, Mingkun Mu, Xiaoyang Liu, Jing Li, Huan Wu, Yanli Liu, Yichun Guan, Bingnan Ren, Shuheng Yang |
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| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty medicine.medical_treatment Birth weight Fertilization in Vitro Intracytoplasmic sperm injection Pregnancy Semen medicine Humans Genetic Testing reproductive and urinary physiology Retrospective Studies Chromosome Aberrations Singleton Obstetrics business.industry Gravidity and parity Infant Newborn Obstetrics and Gynecology Gestational age medicine.disease Embryo Transfer Gestational diabetes Low birth weight Premature Birth Female medicine.symptom business Live Birth |
| Zdroj: | Reproductive sciences (Thousand Oaks, Calif.). 29(10) |
| ISSN: | 1933-7205 |
| Popis: | This study investigated whether singleton pregnancies conceived after preimplantation genetic testing for chromosomal structural rearrangements (PGT-SR) are associated with a higher risk of adverse perinatal outcomes than singleton pregnancies conceived after intracytoplasmic sperm injection (ICSI). We collected data on singleton live births after PGT-SR (n = 107) and ICSI (n = 585) in our hospital from January 2017 to August 2020. Multivariable analyses were used to adjust for maternal age, body mass index, gravidity and parity, paternal age, ovulatory disorder, and recurrent spontaneous abortion. The unadjusted results showed a significantly higher risk of hypertensive disorders of pregnancy (HDP) (odds ratio (OR) = 2.47; 95% confidence interval (CI): 1.10–5.54; P = 0.029) associated with PGT-SR singleton pregnancies than with ICSI singleton pregnancies. However, after adjusting for potential confounders, there were no longer any significant differences in the risk of HDP (adjusted OR = 2.24; 95% CI: 0.92–5.48; P = 0.077) between PGT-SR and ICSI singleton pregnancies. There were no significant differences between PGT-SR and ICSI singleton pregnancies in terms of gestational diabetes, preterm premature rupture of membranes, placenta previa, cesarean delivery, gestational age (weeks), preterm delivery ( |
| Databáze: | OpenAIRE |
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