About the controversies of the cardioprotective effect of n-3 polyunsaturated fatty acids (PUFAs) between animal studies and clinical meta-analyses: a review with several strategies to enhance the beneficial effects of n-3 PUFAs

Autor: Thibault Leger, Kasra Azarnoush, Luc Demaison, Catherine Vergely, Luc Rochette
Přispěvatelé: Unité de Nutrition Humaine - Clermont Auvergne (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne (UCA), EA 7460, Physiologie et Epidémiologie Cérébro-Cardiovasculaire (PEC2), Université de Bourgogne (UB), Chirurgie Cardiaque, Centre Hospitalier Universitaire Gabriel Montpied, Physiopathologie et épidémiologie cérébro-cardiovasculaire [Dijon] (PEC2), Université de Bourgogne (UB)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Unité de Nutrition Humaine (UNH), Institut National de la Recherche Agronomique (INRA)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), CHU Gabriel Montpied [Clermont-Ferrand], CHU Clermont-Ferrand-CHU Clermont-Ferrand, INRA: 1456A
Jazyk: angličtina
Rok vydání: 2019
Předmět:
0301 basic medicine
Cardiotonic Agents
Physiology
030209 endocrinology & metabolism
Myocardial Reperfusion Injury
Pharmacology
Arrhythmias
Biochemistry
03 medical and health sciences
Mice
0302 clinical medicine
Meta-Analysis as Topic
[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system
Fatty Acids
Omega-3
Medicine
Animals
Humans
Survival rate
Beneficial effects
N 3 pufa
ComputingMilieux_MISCELLANEOUS
Cardiac death
chemistry.chemical_classification
Reperfusion arrhythmias
Coronary event
Myocardial tissue
business.industry
Myocardium
food and beverages
Arrhythmias
Cardiac
Heart
General Medicine
3. Good health
Rats
030104 developmental biology
chemistry
Infarction
N-3 PUFAs
Animal studies
Cellular damages
business
Anti-Arrhythmia Agents
[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
Polyunsaturated fatty acid
Zdroj: Journal of Physiology and Biochemistry
Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2019, Epub ahead of print, ⟨10.1007/s13105-019-00670-y⟩
Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2019, 75 (3), pp.241-251. ⟨10.1007/s13105-019-00670-y⟩
Journal of Physiology and Biochemistry, Springer Verlag (Germany), 2019, Epub ahead of print (3), ⟨10.1007/s13105-019-00670-y⟩
Journal of Physiology and Biochemistry, 2019, Epub ahead of print (3), ⟨10.1007/s13105-019-00670-y⟩
ISSN: 1138-7548
Popis: Several meta-analyses describing the effect of n-3 polyunsaturated fatty acids on the survival rate of the victims of an acute coronary event do not clearly support a beneficial impact of these fatty acids. Yet, animal studies consistently show n-3 PUFA-induced protection against ischemia-reperfusion-induced myocardial injuries. The impact on reperfusion arrhythmias of these PUFAs is more controversial. The literature shows the anti-arrhythmic properties of circulating n-3 PUFAs. However, when these fatty acids are incorporated in the cardiac membrane, they protect the myocardial tissue vis a vis cellular damage but they can be either pro- or anti-arrhythmic during reperfusion, depending on the severity of tissue injuries. The latter elements can explain the lack of beneficial effect observed in the meta-analyses, but a proper use of n-3 PUFAs may provide advantages in terms of survival rate. This review discusses the different results obtained in humans and animals and presents several strategies to enhance the beneficial effects of n-3 PUFAs.
Databáze: OpenAIRE
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